C
Carsten P. Ade
Researcher at University of Würzburg
Publications - 28
Citations - 812
Carsten P. Ade is an academic researcher from University of Würzburg. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 12, co-authored 22 publications receiving 498 citations.
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Journal ArticleDOI
NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas
Lydia Meder,Katharina König,Luka Ozretić,Anne M. Schultheis,Frank Ueckeroth,Carsten P. Ade,Kerstin Albus,Diana Boehm,Diana Boehm,Ursula Rommerscheidt-Fuss,Alexandra Florin,Theresa Buhl,Wolfgang Hartmann,Jürgen Wolf,Sabine Merkelbach-Bruse,Martin Eilers,Sven Perner,Sven Perner,Sven Perner,Lukas C. Heukamp,Reinhard Buettner +20 more
TL;DR: A novel pathway underlying rare secondary SCLC which may drive small cell carcinomas in organs other than lung, as well is identified.
Journal ArticleDOI
Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase
Stefanie Peter,Jennyfer Bultinck,Kevin Myant,Laura A. Jaenicke,Susanne Walz,Judith Müller,Michael Gmachl,Matthias Treu,Guido Boehmelt,Carsten P. Ade,Werner Schmitz,Armin Wiegering,Christoph Otto,Nikita Popov,Owen J. Sansom,Norbert Kraut,Martin Eilers +16 more
TL;DR: It is shown here that HUWE1 is required for growth of colorectal cancer cells in culture and in orthotopic xenograft models and identified a novel principle that allows for inhibition of MYC function in tumor cells.
Journal ArticleDOI
OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors
Lisa Anna Jung,Anneli Gebhardt,W. Koelmel,Carsten P. Ade,Susanne Walz,Jochen Kuper,B von Eyss,Sebastian Letschert,C Redel,Luana D’Artista,Andrew V. Biankin,Andrew V. Biankin,Andrew V. Biankin,Lars Zender,Markus Sauer,Elmar Wolf,Gerard I. Evan,Caroline Kisker,Martin Eilers +18 more
TL;DR: The crystal structure of OmoMYC is solved and it is shown that it forms a stable homodimer and as such recognizes DNA in the same manner as the MYC/MAX heterodimer.
Journal ArticleDOI
A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer.
Stefanie Schmidt,Friedrich Wilhelm Uthe,Sarah Denk,Madelon Paauwe,Niels Matthes,Markus E. Diefenbacher,Sheila Bryson,Fiona Clare Warrander,Florian Erhard,Carsten P. Ade,Apoorva Baluapuri,Susanne Walz,Rene Jackstadt,Catriona A. Ford,Georgios Vlachogiannis,Nicola Valeri,Nicola Valeri,Christoph Otto,Christina Schülein-Völk,Katja Maurus,Werner Schmitz,John R. P. Knight,Elmar Wolf,Douglas Strathdee,Almut Schulze,Christoph-Thomas Germer,Andreas Rosenwald,Owen J. Sansom,Martin Eilers,Armin Wiegering +29 more
TL;DR: Pharmacological inhibition of GCN2 phenocopies eIF2B5 depletion and has therapeutic efficacy in tumour organoids demonstrates that a negative MYC–eIF2α feedback loop constitutes a targetable vulnerability of colorectal tumours.
Journal ArticleDOI
Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase
Steffi Herold,Jacqueline Kalb,Gabriele Büchel,Carsten P. Ade,Apoorva Baluapuri,Jiajia Xu,Jan Koster,Daniel Solvie,Anne Carstensen,Christina Klotz,Sabrina Rodewald,Christina Schülein-Völk,Matthias Dobbelstein,Elmar Wolf,Jan J. Molenaar,Rogier Versteeg,Susanne Walz,Martin Eilers +17 more
TL;DR: It is shown that activation of MYCN in human neuroblastoma cells induces escape of RNAPII from promoters, and a cell-lineage-specific stress response enables MYCN-driven tumours to cope with deregulated RNAPII function.