C
C. Balana
Researcher at Complutense University of Madrid
Publications - 15
Citations - 778
C. Balana is an academic researcher from Complutense University of Madrid. The author has contributed to research in topics: Temozolomide & Cancer. The author has an hindex of 10, co-authored 15 publications receiving 614 citations.
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Journal ArticleDOI
Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis
Sebastian Moran,Anna Martínez-Cardús,Sergi Sayols,Eva Musulen,C. Balana,Anna Estival-Gonzalez,Catia Moutinho,Holger Heyn,Angel Diaz-Lagares,Manuel Castro de Moura,Giulia Maria Stella,Paolo M. Comoglio,Maria Ruiz-Miró,Xavier Matias-Guiu,Roberto Pazo-Cid,Antonio Antón,Rafael López-López,Gemma Soler,Federico Longo,Isabel Guerra,Sara Fernandez,Yassen Assenov,Christoph Plass,Rafael Morales,Joan Carles,David D.L. Bowtell,David D.L. Bowtell,Linda Mileshkin,Linda Mileshkin,Daniela Sia,Richard W. Tothill,Richard W. Tothill,Josep Tabernero,Josep M. Llovet,Manel Esteller,Manel Esteller +35 more
TL;DR: The development of a DNA methylation based assay can significantly improve diagnoses of cancer of unknown primary and guide more precise therapies associated with better outcomes.
Journal Article
O6-methyl-guanine-DNA methyltransferase methylation in serum and tumor DNA predicts response to 1,3-bis(2-chloroethyl)-1-nitrosourea but not to temozolamide plus cisplatin in glioblastoma multiforme.
C. Balana,Jose Luis Ramirez,Miquel Taron,Yannis Roussos,Aurelio Ariza,Rosa Ballester,Carme Sarries,Pedro Mendez,Jose Javier Sanchez,Rafael Rosell +9 more
TL;DR: The methylation-specific PCR assay in serum DNA could be a good predictive tool for selecting GBM patients to be treated with BCNU or alternatively with the combination of temozolamide plus cisplatin, with a good correlation between serum and primary tumor tissue.
Journal ArticleDOI
Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program
Maxime Janin,Vanessa Ortiz-Barahona,Manuel Castro de Moura,Anna Martínez-Cardús,Pere Llinàs-Arias,Marta Soler,Daphna Nachmani,Joffrey Pelletier,Ulrike Schumann,Maria E. Calleja-Cervantes,Sebastian Moran,Sonia Guil,Alberto Bueno-Costa,David Piñeyro,Montserrat Pérez-Salvia,Margalida Rosselló-Tortella,Laia Piqué,Joan Josep Bech-Serra,Carolina De La Torre,August Vidal,María Martínez-Iniesta,Juan F. Martín-Tejera,Alberto Villanueva,Alexandra Arias,Isabel Cuartas,Ana M. Aransay,Andres Morales La Madrid,Angel M. Carcaboso,Vicente Santa-Maria,Jaume Mora,Agustín F. Fernández,Mario F. Fraga,Iban Aldecoa,Leire Pedrosa,Francesc Graus,Noemi Vidal,Fina Martínez-Soler,Avelina Tortosa,Cristina Carrato,C. Balana,Matthew W. Boudreau,Paul J. Hergenrother,Peter Kötter,K. D. Entian,Jürgen Hench,Stephan Frank,Sheila Mansouri,Gelareh Zadeh,Pablo D. Dans,Modesto Orozco,George Thomas,George Thomas,Sandra Blanco,Joan Seoane,Joan Seoane,Thomas Preiss,Thomas Preiss,Pier Paolo Pandolfi,Manel Esteller +58 more
TL;DR: It is found that human glioma cells undergo DNA methylation-associated epigenetic silencing of NSUN5, a candidate RNA methyltransferase for 5-methylcytosine, which exhibits tumor-suppressor characteristics in vivo gliomas models and leads to the emergence of an adaptive translational program for survival under conditions of cellular stress.
Journal ArticleDOI
Validation of the new Graded Prognostic Assessment scale for brain metastases: a multicenter prospective study.
Salvador Villà,Damien C. Weber,Cristina Moretones,A. Mañes,Christophe Combescure,Josep Jové,Paloma Puyalto,Patricia Cuadras,Jordi Bruna,Eugenia Verger,C. Balana,Francesc Graus +11 more
TL;DR: The data suggest that the new Graded Prognostic Assessment (GPA) scale in a prospective validation study to compare it with two published prognostic indexes is a valid prognostic index.
Journal ArticleDOI
Bevacizumab plus irinotecan in recurrent malignant glioma shows high overall survival in a multicenter retrospective pooled series of the Spanish Neuro-Oncology Research Group (GEINO).
Miguel J. Gil,Ramon De Las Penas,Gaspar Reynes,C. Balana,Pedro Pérez-Segura,Adelaida García-Velasco,Carlos Mesia,Oscar Gallego,Concepción Fernández-Chacón,Maria Martinez-Garcia,Ana Herrero,Raquel Andrés,Manuel Benavides,Teresa Quintanar,Xavier Pérez-Martin +14 more
TL;DR: Bvacizumab plus irinotecan in recurrent MG improves responses, progression-free survival, and OS compared with historical data.