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Cecilia Garlanda
Researcher at Humanitas University
Publications - 245
Citations - 28805
Cecilia Garlanda is an academic researcher from Humanitas University. The author has contributed to research in topics: Innate immune system & PTX3. The author has an hindex of 76, co-authored 227 publications receiving 24651 citations. Previous affiliations of Cecilia Garlanda include University of Brescia & Mario Negri Institute for Pharmacological Research.
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Journal ArticleDOI
Long Pentraxin 3, a Key Component of Innate Immunity, Is Modulated by High-Density Lipoproteins in Endothelial Cells
Giuseppe Danilo Norata,Patrizia Marchesi,Angela Pirillo,Patrizia Uboldi,Giulia Chiesa,Virginia Maina,Cecilia Garlanda,Alberto Mantovani,Alberico L. Catapano +8 more
TL;DR: Data suggest that part of the atheroprotective effects of HDL could result from the modulation of molecules that act as sensors of the immunoinflammatory balance in the vascular wall.
Journal ArticleDOI
Occurrence and significance of tumor-associated neutrophils in patients with colorectal cancer.
Maria Rosaria Galdiero,Paolo Bianchi,Fabio Grizzi,Giuseppe Di Caro,Gianluca Basso,Andrea Ponzetta,Eduardo Bonavita,Marialuisa Barbagallo,Silvia Tartari,Nadia Polentarutti,Alberto Malesci,Gianni Marone,Massimo Roncalli,Luigi Laghi,Cecilia Garlanda,Alberto Mantovani,Sébastien Jaillon +16 more
TL;DR: Assessment of TAN infiltration in CRC may help identify patients likely to benefit from 5‐FU‐based chemotherapy and call for a reassessment of the role of neutrophils in cancer using rigorous quantitative methodology.
Journal ArticleDOI
The tumor microenvironment of colorectal cancer: stromal TLR-4 expression as a potential prognostic marker
Rosaria Cammarota,Valentina Bertolini,Giuseppina Pennesi,Eraldo O. Bucci,Ornella Gottardi,Cecilia Garlanda,Luigi Laghi,Massimo Barberis,Fausto Sessa,Douglas M. Noonan,Adriana Albini +10 more
TL;DR: It is found that adenocarcinoma patients (pT1-4) with higher TLR-4 expression in stromal compartment had a significantly increased risk in disease progression and those with a diagnosis of pT3 (33 cases) colon cancer, those with very high levels of TLr-4 in the tumor stroma relapsed significantly earlier than those with lower expression levels.
Journal ArticleDOI
An Alternative Role of C1q in Cell Migration and Tissue Remodeling: Contribution to Trophoblast Invasion and Placental Development
Chiara Agostinis,Roberta Bulla,Claudio Tripodo,Angela Gismondi,Helena Stabile,Fleur Bossi,Carla Guarnotta,Cecilia Garlanda,Francesco De Seta,Francesco De Seta,Paola Spessotto,Angela Santoni,Berhane Ghebrehiwet,Guillermina Girardi,Francesco Tedesco +14 more
TL;DR: The data suggest that C1q plays an important role in promoting trophoblast invasion of decidua and that defective local production of C 1q may be involved in pregnancy disorders, such as pre-eclampsia, characterized by poor trophOBlast invasion.
Journal Article
Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR.
Nadia Polentarutti,Giselle Penton Rol,Marta Muzio,Daniela Bosisio,Marco Camnasio,Federica Riva,Carla Zoja,Ariela Benigni,Susanna Tomasoni,Annunciata Vecchi,Cecilia Garlanda,Alberto Mantovani +11 more
TL;DR: TIR8 is a unique member of the IL-1R family, with a distinct pattern of epithelial expression, including the kidney and mucosae, and an inhibitory function onIL-1 signaling, and the extracellular domain was dispensable for blocking activity.