C
Cecilia Krona
Researcher at Uppsala University
Publications - 11
Citations - 213
Cecilia Krona is an academic researcher from Uppsala University. The author has contributed to research in topics: Medulloblastoma & Cell migration. The author has an hindex of 9, co-authored 11 publications receiving 137 citations. Previous affiliations of Cecilia Krona include Boston Children's Hospital & Karolinska Institutet.
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Journal ArticleDOI
Astrocytes enhance glioblastoma growth
Alessandro Mega,Mette Hartmark Nilsen,Lina Wik Leiss,Nicholas P. Tobin,Hrvoje Miletic,Hrvoje Miletic,Linda Sleire,Linda Sleire,Carina Strell,Sven Nelander,Cecilia Krona,Daniel Hägerstrand,Per Øyvind Enger,Monica Nistér,Arne Östman +14 more
TL;DR: It is suggested that astrocytes contribute to glioblastoma growth and implies this crosstalk as a candidate target for novel therapies.
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Integrative discovery of treatments for high-risk neuroblastoma
Elin Almstedt,Ramy Elgendy,Neda Hekmati,Emil Rosén,Caroline Wärn,Thale Kristin Olsen,Cecilia Dyberg,Milena Doroszko,Ida Larsson,Anders Sundström,Marie Henriksson,Sven Påhlman,Daniel Bexell,Michael Vanlandewijck,Michael Vanlandewijck,Per Kogner,Rebecka Jörnsten,Cecilia Krona,Sven Nelander +18 more
TL;DR: An algorithm is introduced that can predict the effect of interventions on gene expression signatures associated with high disease processes and risk, and identify and validate promising drug targets for paediatric and adult cancers.
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A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma
Patrik Johansson,Cecilia Krona,Soumi Kundu,Milena Doroszko,Sathishkumar Baskaran,Linnéa Schmidt,Claire Vinel,Elin Almstedt,Ramy Elgendy,Ludmila Elfineh,Caroline J. Gallant,Sara Lundsten,Fernando J. Ferrer Gago,Aleksi Hakkarainen,Petra Sipilä,Maria Häggblad,Ulf Martens,Bo Lundgren,Melanie M. Frigault,David P. Lane,David P. Lane,Fredrik J. Swartling,Lene Uhrbom,Marika Nestor,Silvia Marino,Sven Nelander +25 more
TL;DR: An integrated pharmacogenomic analysis of 100 patient-derived GBM cell cultures from the human glioma cell culture (HGCC) cohort finds that GBM has two main pharmacological subgroups, marked by differential response to proteasome inhibitors and mutually exclusive aberrations in TP53 and CDKN2A/B.
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Integrin α10, a Novel Therapeutic Target in Glioblastoma, Regulates Cell Migration, Proliferation, and Survival.
Matilda Munksgaard Thorén,Katarzyna Chmielarska Masoumi,Cecilia Krona,Huang Xiaoli,Soumi Kundu,Linnéa Schmidt,Karin Forsberg-Nilsson,Marcus F. Keep,Elisabet Englund,Sven Nelander,Bo Holmqvist,Evy Lundgren-Åkerlund +11 more
TL;DR: It is demonstrated that integrin α10β1 has a functional role in GBM cells and is a novel, potential therapeutic target for the treatment of GBM.
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Mutations in the N-terminal domain of DFF45 in a primary germ cell tumor and in neuroblastoma tumors.
TL;DR: Three different coding alterations have been found in the region encoding the N-terminal regulatory domain of DFF45, responsible for binding and achieving its chaperone and inhibitor functions on other proteins.