C
Cecilia M. Giachelli
Researcher at University of Washington
Publications - 190
Citations - 27487
Cecilia M. Giachelli is an academic researcher from University of Washington. The author has contributed to research in topics: Osteopontin & Calcification. The author has an hindex of 84, co-authored 187 publications receiving 25506 citations. Previous affiliations of Cecilia M. Giachelli include Maine Medical Center & UCLA Medical Center.
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Journal ArticleDOI
Phosphate regulation of vascular smooth muscle cell calcification.
Shuichi Jono,Marc D. McKee,Charles E. Murry,Atsushi Shioi,Yoshiki Nishizawa,Katsuhito Mori,Hirotoshi Morii,Cecilia M. Giachelli +7 more
TL;DR: It is suggested that elevated phosphate may directly stimulate HSMCs to undergo phenotypic changes that predispose to calcification and offer a novel explanation of the phenomenon of vascular calcification under hyperphosphatemic conditions.
Journal ArticleDOI
Smooth Muscle Cell Phenotypic Transition Associated With Calcification Upregulation of Cbfa1 and Downregulation of Smooth Muscle Lineage Markers
Susie Steitz,Mei Y. Speer,Gabrielle Curinga,Hsueh Ying Yang,Paul A. Haynes,Paul A. Haynes,Ruedi Aebersold,Thorsten Schinke,Gerard Karsenty,Cecilia M. Giachelli +9 more
TL;DR: A novel association of vascular calcification with smooth muscle cell phenotypic transition, in which several osteogenic proteins including osteopontin, osteocalcin, and the bone determining factor Cbfa1 are gained is demonstrated, which suggests a positive role for SMCs in promoting vascular calcifying.
Journal ArticleDOI
Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate
TL;DR: A major role is suggested for elevated P in promoting osteogenic/chondrogenic differentiation of VSMC, whereas elevated Ca has a predominant role in promoting VSMC apoptosis and vesicle release.
Journal ArticleDOI
Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques
Cecilia M. Giachelli,Nancy Bae,Manuela Almeida,David T. Denhardt,Charles E. Alpers,Stephen M. Schwartz +5 more
TL;DR: The data implicate osteopontin as a potentially important mediator of arterial neointima formation as well as dystrophic calcification that often accompanies this process.
Journal ArticleDOI
Osteopontin. A Multifunctional Molecule Regulating Chronic Inflammation and Vascular Disease
TL;DR: The role for OPN proteolytic fragments in vivo is almost completely unexplored, and further knowledge of the effects of OPN fragments on cell responses might help in designing therapeutics targeting inflammatory and cardiovascular diseases.