C
Cees J. Tack
Researcher at Radboud University Nijmegen
Publications - 249
Citations - 9552
Cees J. Tack is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Diabetes mellitus & Insulin. The author has an hindex of 46, co-authored 234 publications receiving 8262 citations. Previous affiliations of Cees J. Tack include Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Inflammasome is a central player in the induction of obesity and insulin resistance
Rinke Stienstra,Janna A. van Diepen,Cees J. Tack,Hasan Zaki,Frank L. van de Veerdonk,Deshani Perera,Geoffrey Neale,Guido J. E. J. Hooiveld,Anneke Hijmans,Irene O.C.M. Vroegrijk,Sjoerd A.A. van den Berg,Johannes A. Romijn,Patrick C.N. Rensen,Leo A. B. Joosten,Mihai G. Netea,Thirumala-Devi Kanneganti +15 more
TL;DR: It is demonstrated that mice deficient in Nlrp3, apoptosis-associated speck-like protein, and caspase-1 were resistant to the development of high-fat diet-induced obesity, which correlated with protection from obesity-induced insulin resistance, and inhibition of the inflammasome is suggested as a potential therapeutic strategy.
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The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity
Rinke Stienstra,Leo A. B. Joosten,Tim B. Koenen,Berry van Tits,Janna A. van Diepen,Sjoerd A.A. van den Berg,Patrick C.N. Rensen,Peter J. Voshol,Giamilla Fantuzzi,Anneke Hijmans,Sander Kersten,Michael Müller,Wim B. van den Berg,Nico van Rooijen,Martin Wabitsch,Bart Jan Kullberg,Jos W. M. van der Meer,Thirumala D. Kanneganti,Cees J. Tack,Mihai G. Netea +19 more
TL;DR: The inflammasome is an important regulator of adipocyte function and insulin sensitivity, and caspase-1 inhibition may represent a novel therapeutic target in clinical conditions associated with obesity and insulin resistance.
Journal ArticleDOI
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance.
Mihai G. Netea,Leo A. B. Joosten,Eli C. Lewis,Dalan R. Jensen,Peter J. Voshol,Bart Jan Kullberg,Cees J. Tack,Han van Krieken,Soohyun Kim,Anton F. H. Stalenhoef,Fons A. J. van de Loo,Ineke Verschueren,Leslie K. Pulawa,Shizuo Akira,Robert H. Eckel,Charles A. Dinarello,Wim B. van den Berg,Jos W. M. van der Meer +17 more
TL;DR: Recombinant IL-18 (rIL-18) administered intracerebrally inhibited food intake and reversed hyperglycemia in Il18−/− mice through activation of STAT3 phosphorylation, indicating a new role of IL- 18 in the homeostasis of energy intake and insulin sensitivity.
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Caffeine Can Decrease Insulin Sensitivity in Humans
TL;DR: Caffeine can decrease insulin sensitivity in healthy humans, possibly as a result of elevated plasma epinephrine levels, and peripheral adenosine receptor antagonism does not appear to contribute to this effect.
Journal ArticleDOI
The inflammasome puts obesity in the danger zone.
TL;DR: Data suggest that activation of the inflammasome represents a crucial step in the road from obesity to insulin resistance and type 2 diabetes.