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Chad A. Cowan
Researcher at Beth Israel Deaconess Medical Center
Publications - 133
Citations - 21703
Chad A. Cowan is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 47, co-authored 131 publications receiving 19789 citations. Previous affiliations of Chad A. Cowan include Massachusetts Institute of Technology & Memorial Sloan Kettering Cancer Center.
Papers
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Journal ArticleDOI
Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications
Frank J. T. Staal,Christopher Baum,Chad A. Cowan,Elaine Dzierzak,Salima Hacein-Bey-Abina,Stefan Karlsson,Tsvee Lapidot,Ihor R. Lemischka,Simón Méndez-Ferrer,Harald Mikkers,Kateri A. Moore,Eduardo Moreno,Christine L. Mummery,Catherine Robin,Toshio Suda,M. van Pel,G. Vanden Brink,Jaap Jan Zwaginga,Willem E. Fibbe +18 more
TL;DR: The hematopoietic stem cells (HSC) is the prototype organ-regenerating stem cell (SC) and by far the most studied type of SC in the body as discussed by the authors.
Book ChapterDOI
Genome Editing for Human Gene Therapy
Torsten B. Meissner,Pankaj Mandal,Leonardo M. R. Ferreira,Derrick J. Rossi,Chad A. Cowan,Chad A. Cowan +5 more
TL;DR: This chapter explores the use of the CRISPR/Cas9 system for the efficient ablation of genes in two clinically relevant primary human cell types, CD4+ T cells and CD34+ hematopoietic stem and progenitor cells by using two guide RNAs directed at a single locus.
Journal ArticleDOI
White to brite adipocyte transition and back again
Youn-Kyoung Lee,Chad A. Cowan +1 more
TL;DR: Remarkably, white adipocytes can adopt the characteristics of brite adipocytes following cold stimulation, and this process is reversible in vivo.
Journal ArticleDOI
Humanity in a Dish: Population Genetics with iPSCs.
TL;DR: The recent advances in iPSC cohort studies of common genetic variants and their effects on gene expression and cellular phenotypes are described, and a road map for future in vitro functional population genetic studies and trial-in-a-dish experiments is provided.
Journal ArticleDOI
Adipocyte Metabolism and Insulin Signaling Perturbations: Insights from Genetics.
TL;DR: Genome-wide association studies have begun to illuminate the genetics underlying obesity, T2D, and IR, and this will allow further study into the disease mechanisms of the genes implicated in these metabolic diseases.