S
Simón Méndez-Ferrer
Researcher at University of Cambridge
Publications - 98
Citations - 9534
Simón Méndez-Ferrer is an academic researcher from University of Cambridge. The author has contributed to research in topics: Stem cell & Bone marrow. The author has an hindex of 33, co-authored 84 publications receiving 7997 citations. Previous affiliations of Simón Méndez-Ferrer include Centro Nacional de Investigaciones Cardiovasculares & Icahn School of Medicine at Mount Sinai.
Papers
More filters
Journal ArticleDOI
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
Simón Méndez-Ferrer,Tatyana V. Michurina,Francesca Ferraro,Amin R. Mazloom,Ben D. MacArthur,Ben D. MacArthur,Sergio A. Lira,David T. Scadden,Avi Ma'ayan,Grigori Enikolopov,Paul S. Frenette,Paul S. Frenette +11 more
TL;DR: It is demonstrated that mesenchymal stem cells (MSCs), identified using nestin expression, constitute an essential HSC niche component and are indicative of a unique niche in the bone marrow made of heterotypic stem-cell pairs.
Journal ArticleDOI
Haematopoietic stem cell release is regulated by circadian oscillations
TL;DR: Circadian oscillations are markedly altered when mice are subjected to continuous light or to a ‘jet lag’ (defined as a shift of 12 h) and data indicate that a circadian, neurally driven release of HSC during the animal’s resting period may promote the regeneration of the stem cell niche and possibly other tissues.
Journal ArticleDOI
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
Andrew Chow,Daniel Lucas,Daniel Lucas,Andrés Hidalgo,Andrés Hidalgo,Simón Méndez-Ferrer,Simón Méndez-Ferrer,Daigo Hashimoto,Christoph Scheiermann,Christoph Scheiermann,Michela Battista,Marylene Leboeuf,Colette Prophete,Colette Prophete,Nico van Rooijen,Masato Tanaka,Miriam Merad,Paul S. Frenette,Paul S. Frenette +18 more
TL;DR: Results highlight two antagonistic, tightly balanced pathways that regulate maintenance of HSCs/progenitors in the niche during homeostasis, in which MΦ cross talk with the Nestin+ niche cell promotes retention, and in contrast, SNS signals enhance egress.
Journal ArticleDOI
Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating Toll-like receptor ligands
Chao Shi,Ting Jia,Simón Méndez-Ferrer,Tobias M. Hohl,Natalya V. Serbina,Lauren Lipuma,Ingrid Leiner,Ming O. Li,Paul S. Frenette,Paul S. Frenette,Eric G. Pamer +10 more
TL;DR: It is demonstrated that low concentrations of Toll-like receptor (TLR) ligands in the bloodstream drive CCR2-dependent emigration of monocytes from bone marrow and that bone marrow MSCs and CAR cells respond to circulating microbial molecules and regulate bloodstream monocyte frequencies by secreting MCP1 in proximity to bone marrow vascular sinuses.
Journal ArticleDOI
Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms
Lorena Arranz,Abel Sanchez-Aguilera,Daniel Martín-Pérez,Joan Isern,Xavier Langa,Alexandar Tzankov,Pontus Lundberg,Sandra Muntión,Yi-Shiuan Tzeng,Dar-Ming Lai,Jürg Schwaller,Radek C. Skoda,Simón Méndez-Ferrer +12 more
TL;DR: The results demonstrate that mutant-HSC-driven niche damage critically contributes to disease manifestation in MPN and identify niche-forming MSCs and their neural regulation as promising therapeutic targets.