C
Chad J. Creighton
Researcher at Baylor College of Medicine
Publications - 429
Citations - 78655
Chad J. Creighton is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 88, co-authored 388 publications receiving 62381 citations. Previous affiliations of Chad J. Creighton include University of Michigan & University of Texas MD Anderson Cancer Center.
Papers
More filters
Journal ArticleDOI
Constitutive expression of progesterone receptor isoforms promotes the development of hormone-dependent ovarian neoplasms.
Margeaux Wetendorf,Margeaux Wetendorf,Rong Li,San-Pin Wu,Jian Liu,Chad J. Creighton,Tianyuan Wang,Kyathanahalli S. Janardhan,Cynthia J. Willson,Rainer B. Lanz,Bruce D. Murphy,John P. Lydon,Francesco J. DeMayo +12 more
TL;DR: A mechanism whereby an increase in the abundance of PGRB relative to that of PGRA drives neoplasia in vivo by stimulating cell cycling is suggested, which may explain why an imbalance in the isoform ratio is associated with reproductive tract cancers in women.
Proceedings ArticleDOI
High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines Correlates with Sensitivity to IGF-IR Inhibitor BMS-754807 in This Subtype of Human Breast Cancer.
Beate C. Litzenburger,Anna Tsimelzon,SG Hilsenbeck,Chad J. Creighton,J. Carboni,Marco M. Gottardis,Max S. Wicha,Jenny C. Chang,Michael T. Lewis,Adrian V. Lee +9 more
TL;DR: The data indicates that the IGF-I pathway is highly active in TN breast cancer and this study provides the preclinical rationale for targeting IGF-IR in this subtype of human breast cancer.
Journal ArticleDOI
The Cancer Genome Atlas Project on Muscle-invasive Bladder Cancer.
Seth P. Lerner,John N. Weinstein,David J. Kwiatkowski,David J. Kwiatkowski,Jaegil Kim,Gordon Robertson,Katherine A. Hoadley,Rehan Akbani,Chad J. Creighton +8 more
TL;DR: The Cancer Genome Atlas project in bladder cancer reported the integrated genomic analysis of the first 131 patients in 2014, and this muscle-invasive cohort was found to have one of the highest somatic mutation rates.
Journal ArticleDOI
Decrease in tumorigenic breast cancer stem cells – final results of a neoadjuvant trial in primary breast cancer patients
Angel Rodriguez,Jerry Cha-Jan Chang,Xiao-Nan Li,Chad J. Creighton,Helen Wong,SG Hilsenbeck,Anne Pavlick,CK Osborne,M. Wu,Jeffrey M. Rosen,Michael T. Lewis +10 more
Posted ContentDOI
Genomic rearrangements near genes leading to upregulation across a diverse subset of human cancers
TL;DR: Using a dataset of somatic Structural Variants (SVs) in cancers from 2658 patients, hundreds of genes for which the nearby presence (within 100kb) of an SV breakpoint was associated with altered expression were identified.