C
Chad J. Creighton
Researcher at Baylor College of Medicine
Publications - 429
Citations - 78655
Chad J. Creighton is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 88, co-authored 388 publications receiving 62381 citations. Previous affiliations of Chad J. Creighton include University of Michigan & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer
Jun Hyoung Park,Sajna Antony Vithayathil,Santosh Kumar,Pi Lin Sung,Pi Lin Sung,Lacey E. Dobrolecki,Vasanta Putluri,Vadiraja B. Bhat,Salil Kumar Bhowmik,Vineet Gupta,Kavisha Arora,Danli Wu,Efrosini Tsouko,Yiqun Zhang,Suman Maity,Taraka R. Donti,Brett H. Graham,Daniel E. Frigo,Daniel E. Frigo,Cristian Coarfa,Patricia Yotnda,Nagireddy Putluri,Arun Sreekumar,Michael T. Lewis,Chad J. Creighton,Lee-Jun C. Wong,Benny Abraham Kaipparettu +26 more
TL;DR: Analysis of cybrids and established breast cancer cell lines showed that metastatic TNBC maintains high levels of ATP through fatty acid β oxidation (FAO) and activates Src oncoprotein through autophosphorylation at Y419, and confirmed the role of mitochondrial FAO in Src activation and metastasis.
Journal ArticleDOI
Comprehensive molecular characterization of mitochondrial genomes in human cancers
Yuan Yuan,Young Seok Ju,Young-Wook Kim,Jun Li,Yumeng Wang,Yumeng Wang,Christopher J. Yoon,Yang Yang,Inigo Martincorena,Chad J. Creighton,John N. Weinstein,Yanxun Xu,Leng Han,Hyung Lae Kim,Hidewaki Nakagawa,Keunchil Park,Peter J. Campbell,Peter J. Campbell,Han Liang,Han Liang +19 more
TL;DR: This analysis presents the most definitive mutational landscape of mitochondrial genomes and identifies several hypermutated cases, frequent somatic nuclear transfer of mt DNA and high variability of mtDNA copy number in many cancers.
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VEGF Drives Cancer-Initiating Stem Cells Through VEGFR-2/Stat3 Signaling to Upregulate Myc and Sox2
Dekuang Zhao,Chendong Pan,Jun Sun,Candace A Gilbert,Katherine Drews-Elger,Diana J. Azzam,Manuel Picon-Ruiz,Minsoon Kim,W. Ullmer,Dorraya El-Ashry,Chad J. Creighton,Joyce M. Slingerland +11 more
TL;DR: High-VEGF tumors may be most likely to escape anti-angiogenics by upregulating VEGF, driving CSC self-renewal to re-populate post-treatment, and highlights the need to better define V EGF-driven cancer subsets and supports further investigation of combined therapeutic blockade of VEGFR-2 and JAK2/STAT3.
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Cleavage of Fibrinogen by Proteinases Elicits Allergic Responses Through Toll-Like Receptor 4
Valentine O. Millien,Wen Lu,Joanne Shaw,Xiaoyi Yuan,Garbo Mak,Luz Roberts,Li Zhen Song,J. Morgan Knight,Chad J. Creighton,Amber U Luong,Farrah Kheradmand,David B. Corry +11 more
TL;DR: It is demonstrated that TLR4 is activated by airway proteinase activity to initiate both allergic airway disease and antifungal immunity, which clarifies the molecular basis of allergic disease and suggest new therapeutic strategies.
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Change in neutrophil-to-lymphocyte ratio (NLR) in response to immune checkpoint blockade for metastatic renal cell carcinoma
Aly-Khan A. Lalani,Wanling Xie,Dylan J. Martini,Dylan J. Martini,John A. Steinharter,Craig Norton,Katherine M. Krajewski,Audrey Duquette,Dominick Bossé,Joaquim Bellmunt,Eliezer M. Van Allen,Eliezer M. Van Allen,Bradley Alexander McGregor,Chad J. Creighton,Lauren C. Harshman,Toni K. Choueiri +15 more
TL;DR: Early decline and NLR at 6 weeks are associated with significantly improved outcomes in mRCC patients treated with ICB, and the prognostic value of the readily-available NLR warrants larger, prospective validation.