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Chad J. Creighton
Researcher at Baylor College of Medicine
Publications - 429
Citations - 78655
Chad J. Creighton is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 88, co-authored 388 publications receiving 62381 citations. Previous affiliations of Chad J. Creighton include University of Michigan & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Improved prediction of disease-free survival in tamoxifen-treated patients using an expression signature of estrogen-regulated genes as compared to progesterone receptor
TL;DR: Through RT-PCR assay of a larger independent cohort of breast tumor samples, this work is currently validating the prognostic value of individual genes within the 36-gene signature of Progesterone receptor, a direct downstream target of activated estrogen receptor (ER).
Proceedings ArticleDOI
Abstract 2969: Progress in The Cancer Genome Atlas bladder cancer project
John N. Weinstein,Jaegil Kim,Chad J. Creighton,Rehan Akbani,Katherine A. Hoadley,William Y. Kim,Margaret B. Morgan,Toshinori Hinoue,Andrew D. Cherniack,Xiaoping Su,Andrew J. Mungall,Michael C. Ryan,Dean F. Bajorin,Jonathan E. Rosenberg,Bogdan Czerniak,Donna E. Hansel,Victor E. Reuter,Brian D. Robinson,Hikmat Al-Ahmadie,Jeffrey S. Damrauer,Wei Zhang,Yuexin Liu,Dmitry R. Gordenin,Joshua M. Stuart,Nikolaus Schultz,Gordon Robertson,Steven J.M. Jones,Raju R. Kucherlapati,David J. McConkey,Peter W. Laird,Gordon B. Mills,David J. Kwiatkowski,Seth P. Lerner +32 more
TL;DR: Three mutation clusters were identified and characterized as: 1) “Focally amplified” - enriched in focal copy number alterations; 2) Enriched for TP53 and RB1 mutations, E2F3 amplifications; and 3) Papillary histology, FGFR3 mutant CDKN2A-deficient.
Journal ArticleDOI
1633 targeting the neural microenvironment in prostate cancer: a neoadjuvant botox clinical trial
Gustavo Ayala,Diego Florentin,Jason Au,Yi Ding,Dandan He,Chad J. Creighton,Anna Frolov,Olga Dakhova,Yiqun Zhang,Christopher Irwin Smith,Dov Kadmon,Brian J. Miles,Michael Ittmann,David R. Rowley +13 more
Journal ArticleDOI
B376 The Role of MicroRNAs in Dexamethasone Response and Glucocorticoid Resistance in Multiple Myeloma
Journal ArticleDOI
Ablating Lgr5-expressing prostatic stromal cells activates the ERK-mediated mechanosensory signaling and disrupts prostate tissue homeostasis
Xing Wei,Lin Zhang,Yi-qing Zhang,Cody Cooper,Chris M. Brewer,Chia-Feng Tsai,Yi-Ting Wang,Micah S. Glaz,Hunter Wessells,Jianwen Que,Mark Titus,Vincenzino Cirulli,Adam K. Glaser,Tao Li,Nicholas P. Reder,Chad J. Creighton,Li Xin +16 more
TL;DR: In this paper , the authors used lineage tracing and light-sheet imaging to show that some fibroblast cells at the proximal prostatic ducts and prostatic urethra highly express Lgr5.