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Chad J. Creighton
Researcher at Baylor College of Medicine
Publications - 429
Citations - 78655
Chad J. Creighton is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 88, co-authored 388 publications receiving 62381 citations. Previous affiliations of Chad J. Creighton include University of Michigan & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Efficient cancer modeling through CRISPR-Cas9/HDR-based somatic precision gene editing in mice
Wen Bu,Chad J. Creighton,Kelsey S Heavener,Carolina Gutierrez,Yongchao Dou,Amy T. Ku,Yi-qing Zhang,Wei-meng Jiang,Wen Jiang,Fei Yue,Luyu Jia,Ahmed Atef Ibrahim,Bing Hua Zhang,Shixia Huang,Yi Li +14 more
TL;DR: This paper used homology-directed repair to enable precise editing of any proto-oncogene in murine somatic tissues to generate tumor models with high flexibility and efficiency, which can be used to study human tumor evolution and therapeutic development.
Journal ArticleDOI
Distinct MET alterations to induce a common phenotype and to define a MET-driven subset of papillary RCC: Results from the Cancer Genome Atlas (TCGA) Kidney Renal Papillary (KIRP) Working Group.
Laurence Albiges,Bradley A. Murray,Angela N. Brooks,Andrew D. Cherniack,Alice H. Berger,Chad J. Creighton,Christopher J. Ricketts,Donald P. Bottaro,Ramaprasad Srinivasan,Laura S. Schmidt,Matthew Meyerson,Paul T. Spellman,W. Marston Linehan,Toni K. Choueiri +13 more
TL;DR: The distinct molecular alterations of MET and their impact within the TCGA KIRP dataset are reported and predicted to be constitutively activated.
Proceedings ArticleDOI
Abstract PD8-03: ESR1 gene fusions drive endocrine therapy resistance and metastasis in breast cancer
Jonathan T. Lei,Jieya Shao,Jing Zhang,Michael D. Iglesia,DW Chan,Jin Cao,Meenakshi Anurag,Puneet Singh,Svasti Haricharan,Shyam M. Kavuri,Ryoichi Matsunuma,Cheryl Schmidt,Yoshimasa Kosaka,Robert J. Crowder,Jeremy Hoog,Chanpheng Phommaly,Rodrigo Franco Gonçalves,Susana Ramalho,Raquel Mary Rodrigues-Peres,W-C Lai,Oliver A. Hampton,Anna Rogers,Ethan Tobias,P Parikh,Sherri R. Davies,Cynthia X. Ma,Vera J. Suman,K. K. Hunt,Mark F. Watson,Katherine A. Hoadley,A. Thompson,CM Perou,Chad J. Creighton,Christopher A. Maher,MJ Ellis +34 more
TL;DR: ESR1-YAP1 and ESR1-PCDH11x are driver fusions that occur in drug-resistant, advanced stage breast cancer and are a new class of recurrent somatic mutation that can cause acquired endocrine therapy resistance, yet can be treated with CDK4/6 inhibition.
Journal ArticleDOI
Functional characterization of age-dependent p16 epimutation reveals biological drivers and therapeutic targets for colorectal cancer
Li Yang,Xiao Chen,Jiejun Shi,Lanjing Zhang,Yumei Li,Nan Gao,Sung Yun Jung,Chad J. Creighton,Jingyi Jessica Li,Ya Cui,Sumimasa Arimura,Yunping Lei,Wei Li,Lanlan Shen +13 more
TL;DR: In this article , the role of age-related p16 epimutation in intestinal tumorigenesis was explored in a mouse model that replicates two common genetic and epigenetic events observed in human colorectal cancer.
Journal ArticleDOI
Plk2 regulates mitotic spindle orientation and mammary gland development
Elizabeth Villegas,Elena B. Kabotyanski,Amy N. Shore,Chad J. Creighton,Thomas F. Westbrook,Jeffrey M. Rosen +5 more
TL;DR: In this article, a role for Plk2 in regulating the orientation of the mitotic spindle and maintaining proper cell polarity in the ductal epithelium was discovered.