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Chandani Limbad
Researcher at Buck Institute for Research on Aging
Publications - 16
Citations - 1860
Chandani Limbad is an academic researcher from Buck Institute for Research on Aging. The author has contributed to research in topics: Senescence & Cell growth. The author has an hindex of 9, co-authored 13 publications receiving 1291 citations. Previous affiliations of Chandani Limbad include New York University & University of California, Berkeley.
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Journal ArticleDOI
MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
Remi-Martin Laberge,Yu Sun,Arturo V. Orjalo,Christopher K. Patil,Adam Freund,Lili Zhou,Samuel C. Curran,Albert R. Davalos,Kathleen A. Wilson-Edell,Su Liu,Chandani Limbad,Marco Demaria,Patrick Wai-Lun Li,Gene B. Hubbard,Yuji Ikeno,Martin A. Javors,Pierre Yves Desprez,Christopher C. Benz,Pankaj Kapahi,Peter S. Nelson,Judith Campisi +20 more
TL;DR: It is shown that rapamycin selectively blunts the pro-inflammatory phenotype of senescent cells, which might ameliorate age-related pathologies, including late-life cancer, by suppressing senescence-associated inflammation.
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Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease
Shankar J. Chinta,Georgia Woods,Marco Demaria,Anand Rane,Ying Zou,Amanda McQuade,Subramanian Rajagopalan,Chandani Limbad,David T. Madden,Judith Campisi,Julie K. Andersen +10 more
TL;DR: It is demonstrated that senescent cell markers are preferentially present within astrocytes in PD brain tissues and that exposure to certain environmental toxins promotes accumulation of senescent cells in the aging brain, which can contribute to dopaminergic neurodegeneration.
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Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
Sean D. McAllister,Ryuichi Murase,Rigel T. Christian,Darryl Lau,Anne J. Zielinski,Juanita Allison,Carolina Almanza,Arash Pakdel,Jasmine G. Lee,Chandani Limbad,Yong Liu,Robert J. Debs,Dan H. Moore,Pierre-Yves Desprez +13 more
TL;DR: It is shown that CBD inhibits human breast cancer cell proliferation and invasion through differential modulation of the extracellular signal-regulated kinase (ERK) and reactive oxygen species (ROS) pathways, and that both pathways lead to down-regulation of Id-1 expression.
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Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
Jahan P. Marcu,Rigel T. Christian,Darryl Lau,Anne J. Zielinski,Maxx P. Horowitz,Jasmine G. Lee,Arash Pakdel,Juanita Allison,Chandani Limbad,Dan Moore,Garret Yount,Pierre-Yves Desprez,Sean D. McAllister +12 more
TL;DR: Cannabidiol, the second most abundant plant-derived cannabinoid, in combination with Δ9-THC is tested and it is suggested that the addition of cannabidiole may improve the overall effectiveness of Δ9 -THC in the treatment of glioblastoma in cancer patients.
Journal ArticleDOI
Id-1 Is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target
Liliana Soroceanu,Ryuichi Murase,Chandani Limbad,Eric Singer,Juanita Allison,Isabel Adrados,Rumi Kawamura,Arash Pakdel,Yayoi Fukuyo,Daniel Nguyen,Sabeena Khan,Robert Arauz,Garret Yount,Dan H. Moore,Pierre-Yves Desprez,Sean D. McAllister +15 more
TL;DR: It is shown that the transcriptional regulator Id-1 plays a critical role in modulating the invasiveness of glioblastoma cell lines and primary gliablastoma cells, and that drugs targeting Id- 1 represent a novel and promising strategy for improving the therapy and outcome of patients with gliOBlastoma.