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Amanda McQuade
Researcher at University of California, Irvine
Publications - 13
Citations - 1085
Amanda McQuade is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Microglia & TREM2. The author has an hindex of 7, co-authored 10 publications receiving 547 citations. Previous affiliations of Amanda McQuade include Buck Institute for Research on Aging & University of California, Berkeley.
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Journal ArticleDOI
Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease
Shankar J. Chinta,Georgia Woods,Marco Demaria,Anand Rane,Ying Zou,Amanda McQuade,Subramanian Rajagopalan,Chandani Limbad,David T. Madden,Judith Campisi,Julie K. Andersen +10 more
TL;DR: It is demonstrated that senescent cell markers are preferentially present within astrocytes in PD brain tissues and that exposure to certain environmental toxins promotes accumulation of senescent cells in the aging brain, which can contribute to dopaminergic neurodegeneration.
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Development and validation of a simplified method to generate human microglia from pluripotent stem cells
Amanda McQuade,Morgan A. Coburn,Christina H. Tu,Jonathan Hasselmann,Hayk Davtyan,Mathew Blurton-Jones +5 more
TL;DR: This updated approach avoids the prior requirement for hypoxic incubation, complex media formulation, FACS sorting, or co-culture, thereby significantly simplifying human microglial generation and enabling many interested labs, including those with little prior stem cell or flow cytometry experience, to generate and study human iPS-microglia.
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Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo.
Jonathan Hasselmann,Morgan A. Coburn,Whitney England,Dario X. Figueroa Velez,Sepideh Kiani Shabestari,Christina H. Tu,Amanda McQuade,Mahshad Kolahdouzan,Karla Echeverria,Christel Claes,Taylor Nakayama,Ricardo Azevedo,Nicole G. Coufal,Claudia Z. Han,Brian J. Cummings,Hayk Davtyan,Christopher K. Glass,Luke M. Healy,Sunil P. Gandhi,Robert C. Spitale,Mathew Blurton-Jones +20 more
TL;DR: It is demonstrated that the iPSC-derived hematopoietic-progenitors implanted into the postnatal brain of humanized, immune-deficient mice provides a powerful new system to examine the in vivo function of patient-derived and genetically modified microglia.
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Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.
Amanda McQuade,You Jung Kang,Jonathan Hasselmann,Amit Jairaman,Alexandra Sotelo,Morgan A. Coburn,Sepideh Kiani Shabestari,Jean Paul Chadarevian,Gianna M. Fote,Christina H. Tu,Emma Danhash,Jorge Silva,Eric S. Martinez,Carl W. Cotman,G. Aleph Prieto,G. Aleph Prieto,Leslie M. Thompson,Joan S. Steffan,Ian F. Smith,Hayk Davtyan,Michael D. Cahalan,Hansang Cho,Mathew Blurton-Jones +22 more
TL;DR: It is found that TREM2 deletion reduces microglial survival, impairs phagocytosis of key substrates including APOE, and inhibits SDF-1α/CXCR4-mediated chemotaxis, culminating in an impaired response to beta-amyloid plaques in vivo.
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Microglia in Alzheimer's Disease: Exploring How Genetics and Phenotype Influence Risk.
TL;DR: It is likely only by combining the above approaches will the field fully elucidate the molecular pathways that regulate microglia and influence neurodegeneration, in turn uncovering potential new targets for future therapeutic development.