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Chara Malapani
Researcher at Columbia University
Publications - 25
Citations - 3227
Chara Malapani is an academic researcher from Columbia University. The author has contributed to research in topics: Basal ganglia & Cognition. The author has an hindex of 22, co-authored 25 publications receiving 3098 citations. Previous affiliations of Chara Malapani include French Institute of Health and Medical Research & University of York.
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Journal ArticleDOI
Toward a neurobiology of temporal cognition: advances and challenges
TL;DR: It is proposed that cerebellar dysfunction may induce deregulation of tonic thalamic tuning, which disrupts gating of the mnemonic temporal information generated in the basal ganglia through striato-thalamo-cortical loops.
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Coupled Temporal Memories in Parkinson's Disease: A Dopamine-Related Dysfunction
Chara Malapani,Brian C. Rakitin,Richard Levy,Warren H. Meck,Bernard Deweer,Bruno Dubois,John Gibbon +6 more
TL;DR: Patients with Parkinson's disease were studied in temporal reproduction tasks and a mutual attraction between temporal processing systems, in memory and clock stages, when dopaminergic regulation in the striatum is dysfunctional is discussed.
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Scalar expectancy theory and peak-interval timing in humans.
TL;DR: It is demonstrated that humans show the same qualitative timing properties that other animals do, but with some quantitative differences.
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Transient overexpression of striatal D2 receptors impairs operant motivation and interval timing.
Michael R. Drew,Eleanor H. Simpson,Christoph Kellendonk,William G. Herzberg,William G. Herzberg,Olga Lipatova,Olga Lipatova,Stephen Fairhurst,Eric R. Kandel,Chara Malapani,Peter D. Balsam,Peter D. Balsam +11 more
TL;DR: It is suggested that early D2 overexpression alters the organization of interval timing circuits and confirms that striatal D2 signaling in the adult regulates motivational process, as well as under pathological conditions such as schizophrenia and Parkinson's disease.
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Separating Storage from Retrieval Dysfunction of Temporal Memory in Parkinson's Disease
TL;DR: A dissociation between deficits in storage (writing to) and retrieval (reading from) temporal memory processes is shown, which are dysfunctional in PD and sensitive to treatment with dopaminergic agents, but produce dissimilar distortions.