C
Charlotta Böiers
Researcher at Lund University
Publications - 30
Citations - 957
Charlotta Böiers is an academic researcher from Lund University. The author has contributed to research in topics: Haematopoiesis & Progenitor cell. The author has an hindex of 14, co-authored 26 publications receiving 770 citations. Previous affiliations of Charlotta Böiers include University College London.
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Journal ArticleDOI
Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells
Charlotta Böiers,Joana Carrelha,Michael Lutteropp,Sidinh Luc,Joanna C. A. Green,Emanuele Azzoni,Petter S. Woll,Adam J. Mead,Anne Hultquist,Gemma Swiers,Elisa Gomez Perdiguero,Iain C. Macaulay,Luca Melchiori,Tiago C. Luis,Shabnam Kharazi,Tiphaine Bouriez-Jones,Qiaolin Deng,Annica Pontén,Deborah Atkinson,Christina Jensen,Ewa Sitnicka,Frederic Geissmann,Isabelle Godin,Rickard Sandberg,Marella F. T. R. de Bruijn,Sten Eirik W. Jacobsen,Sten Eirik W. Jacobsen +26 more
TL;DR: It is demonstrated that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor.
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LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis.
Nieves Peltzer,Maurice Darding,Antonella Montinaro,Peter Draber,Peter Draber,Helena Draberova,Helena Draberova,Sebastian Kupka,Eva Rieser,Amanda Fisher,J. Ciaran Hutchinson,Lucia Taraborrelli,Torsten Hartwig,Elodie Lafont,Tobias L. Haas,Yutaka Shimizu,Charlotta Böiers,Aida Sarr,James A Rickard,James A Rickard,Silvia Alvarez-Diaz,Silvia Alvarez-Diaz,Michael Ashworth,Allison M. Beal,Tariq Enver,John Bertin,William J. Kaiser,Andreas Strasser,Andreas Strasser,John Silke,John Silke,Philippe Bouillet,Philippe Bouillet,Henning Walczak +33 more
TL;DR: The results demonstrate that both HOIP and HOIL-1 are essential LUBAC components and are required for embryogenesis by preventing aberrant cell death and reveal that when LUBac and caspase-8 are absent, RIPK3 prevents RIPK1 from inducing embryonic lethality by causing defects in fetal haematopoiesis.
Journal ArticleDOI
Effect of high-fat diet, surrounding temperature, and enterostatin on uncoupling protein gene expression.
TL;DR: The results suggest that the regulation of uncoupling protein mRNA levels by high-fat feeding is dependent on ambient temperature and that enterostatin is able to modulate it.
Journal ArticleDOI
A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1
Charlotta Böiers,Simon Richardson,Emma Laycock,Alya Zriwil,Virginia Turati,John Brown,Jason Wray,Dapeng Wang,Chela James,Javier Herrero,Ewa Sitnicka,Stefan Karlsson,Andrew J.H. Smith,Andrew J.H. Smith,Sten Erik W. Jacobsen,Tariq Enver +15 more
TL;DR: Describing the first emerging B cells in first-trimester human embryos, identifying a developmentally restricted CD19−IL-7R+ progenitor compartment, which transitions from a myeloid to lymphoid program during ontogeny, provides a model for the initiation of cALL.
Journal ArticleDOI
FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B lymphopoiesis.
Christina Jensen,Christina Jensen,Shabnam Kharazi,Charlotta Böiers,Min Cheng,Anna Lübking,Ewa Sitnicka,Sten Eirik W. Jacobsen,Sten Eirik W. Jacobsen +8 more
TL;DR: It is demonstrated that, rather than TSLP, IL-7 and FLT3 ligand are combined responsible for all B-cell generation in mice, including recently identified B-1-specified cell progenitors, which regulates alternative pathways of fetal and adult B- 1 and B-2 lymphopoiesis.