Virginia Turati

TL;DR: In this article, the authors collated whole-exome and transcriptomic data for >1,000 CPI-treated patients across seven tumor types, utilizing standardized bioinformatics workflows and clinical outcome criteria to validate multivariable predictors of CPI sensitization.

TL;DR: It is suggested that ALL patients might profit from therapeutic strategies that release MRD cells from the niche, as resistant, dormant cells became sensitive to treatment and started proliferating when dissociated from the in vivo environment.

TL;DR: A survey of T cell repertoire evolution in the tumors, healthy tissue and blood of patients with early-stage untreated lung cancer offers an opportunity to monitor and identify neoantigen-specific T cells for personalized immunotherapy.

TL;DR: Tumour mutational burden was associated with compartment-wide T cell differentiation skewing, characterized by loss of TCF7-expressing progenitor-like CD4 T cells, and an increased abundance of dysfunctional CD8 andCD4 T cell subsets, with significant phenotypic and transcriptional similarity to neoantigen-reactive CD8 T cells.

TL;DR: Describing the first emerging B cells in first-trimester human embryos, identifying a developmentally restricted CD19−IL-7R+ progenitor compartment, which transitions from a myeloid to lymphoid program during ontogeny, provides a model for the initiation of cALL.