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Charlotte M. Vines
Researcher at University of Texas at El Paso
Publications - 35
Citations - 1297
Charlotte M. Vines is an academic researcher from University of Texas at El Paso. The author has contributed to research in topics: C-C chemokine receptor type 7 & Receptor. The author has an hindex of 20, co-authored 30 publications receiving 1184 citations. Previous affiliations of Charlotte M. Vines include University of New Mexico & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4–ERK5 axis
Ling Wu,Xing Chen,Junjie Zhao,Bradley N. Martin,Jarod A. Zepp,Jennifer S. Ko,Chunfang Gu,Gang Cai,Wenjun Ouyang,Ganes C. Sen,George Stark Stark,Bing Su,Charlotte M. Vines,Cathy Tournier,Thomas A. Hamilton,Allison T. Vidimos,Brian R. Gastman,Caini Liu,Xiaoxia Li +18 more
TL;DR: A novel IL- 17–mediated cascade via the IL-17R–TRAF4–ERK5 axis that directly stimulates keratinocyte proliferation and skin tumor formation in mice is reported.
Journal ArticleDOI
Arrestins block G protein-coupled receptor-mediated apoptosis.
TL;DR: It is demonstrated that in cells devoid of arrestins, the stimulation of numerous GPCRs including the N-formyl peptide receptor (FPR) initiates rapid cell rounding, annexin V positivity, and caspase activation followed by cell death followed by apoptosis.
Journal Article
Drug and Radiation Sensitivity Measurements of Successful Primary Monolayer Culturing of Human Tumor Cells Using Cell-adhesive Matrix and Supplemented Medium
Fraser L. Baker,Gary Spitzer,Jaffer A. Ajani,William A. Brock,John M. Lukeman,Sen Pathak,Barbara Tomasovic,Diva Thielvoldt,Marcia Williams,Charlotte M. Vines,Philip J. Tofilon +10 more
TL;DR: This method for growing cells from primary human biopsy specimens is more efficient than the agar culture method, enables easier and better biological analysis of the actual cells grown, and permits improved characterization of drug and radiation survival curves.
Journal ArticleDOI
N-formyl peptide receptors internalize but do not recycle in the absence of arrestins.
Charlotte M. Vines,Chetana M. Revankar,Diane C. Maestas,Leah L. LaRusch,Daniel F. Cimino,Trudy A. Kohout,Robert J. Lefkowitz,Eric R. Prossnitz +7 more
TL;DR: Observations indicate that, although the FPR can internalize in the absence of arrestins, recycling of internalized receptors to the cell surface is prevented, and suggest a novel role for arrestins in the post-endocytic trafficking of GPCRs.
Journal ArticleDOI
Negative Regulation of Phagocytosis in Murine Macrophages by the Src Kinase Family Member, Fgr
Hattie D. Gresham,Benjamin M. Dale,Benjamin M. Dale,Jeffrey W. Potter,Peter W. Chang,Charlotte M. Vines,Clifford A. Lowell,Carl F. Lagenaur,Cheryl L. Willman +8 more
TL;DR: An important negative regulatory role is demonstrated for this Src kinase family member on opsonin-dependent phagocytosis by mouse macrophages and it is suggested that this homeostatic function must be overcome for optimal uptake and clearance of opsonized pathogens.