C
Cheng-Yu Chung
Researcher at Johns Hopkins University
Publications - 22
Citations - 627
Cheng-Yu Chung is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Chinese hamster ovary cell & Glycan. The author has an hindex of 13, co-authored 19 publications receiving 509 citations. Previous affiliations of Cheng-Yu Chung include National Tsing Hua University.
Papers
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Journal ArticleDOI
CHO microRNA engineering is growing up: Recent successes and future challenges
Vaibhav Jadhav,Matthias Hackl,Aliaksandr Druz,Aliaksandr Druz,Smriti Shridhar,Cheng-Yu Chung,Kelley M. Heffner,David P. Kreil,David P. Kreil,Michael J. Betenbaugh,Joseph Shiloach,Niall Barron,Johannes Grillari,Nicole Borth +13 more
TL;DR: Both knowledge on the regulatory mechanisms of microRNAs obtained from other biological models and proof of concepts already performed on CHO cells are discussed, providing an outlook of potential applications of microRNA engineering in production cell lines.
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Glycoengineering of Chinese hamster ovary cells for enhanced erythropoietin N-glycan branching and sialylation
Bojiao Yin,Yuan Gao,Cheng-Yu Chung,Shuang Yang,Emily Blake,Mark C. Stuczynski,Juechun Tang,Helene Faustrup Kildegaard,Mikael Rørdam Andersen,Hui Zhang,Michael J. Betenbaugh +10 more
TL;DR: In this paper, a human α2,6-sialyltransferase (ST6Gal1) was expressed in Chinese hamster ovary (CHO-K1) cells.
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Enterovirus 71 virus-like particle vaccine: improved production conditions for enhanced yield
Cheng-Yu Chung,Chi-Yuan Chen,Shih-Yeh Lin,Yao-Chi Chung,Hsin-Yi Chiu,Wei Kuang Chi,Yu-Li Lin,Bor-Luen Chiang,Wei-Jheng Chen,Yu-Chen Hu +9 more
TL;DR: The constructed Bac-P1-C3CD and the bioprocess render mass production more economical, obviate the need for cell lysis and hold promise for future industrial vaccine production.
Journal ArticleDOI
Antibody glycoengineering strategies in mammalian cells.
TL;DR: By applying multiple complementary intracellular and extracellular strategies, biotechnologists are well on their ways to precisely tuning antibody glycoforms emerging from bioreactors in the coming decades.
Journal ArticleDOI
SnapShot: N-Glycosylation Processing Pathways across Kingdoms.
TL;DR: This SnapShot presents the core pathways from different organisms that install these complex and highly variable structures.