L
Leonie Unterholzner
Researcher at Lancaster University
Publications - 21
Citations - 4956
Leonie Unterholzner is an academic researcher from Lancaster University. The author has contributed to research in topics: DNA & Innate immune system. The author has an hindex of 15, co-authored 20 publications receiving 4265 citations. Previous affiliations of Leonie Unterholzner include European Bioinformatics Institute & Trinity College, Dublin.
Papers
More filters
Journal ArticleDOI
IFI16 is an innate immune sensor for intracellular DNA.
Leonie Unterholzner,Sinead E. Keating,Marcin Baran,Kristy A. Horan,Søren B. Jensen,Søren B. Jensen,Shrutie Sharma,Cherilyn M. Sirois,Tengchuan Jin,Eicke Latz,Eicke Latz,T. Sam Xiao,Katherine A. Fitzgerald,Søren R. Paludan,Andrew G. Bowie +14 more
TL;DR: IFI16 (p204) is the first PYHIN protein to their knowledge shown to be involved in IFN-β induction and forms a new family of innate DNA sensors the authors call 'AIM2-like receptors' (ALRs).
Journal ArticleDOI
Viral evasion and subversion of pattern-recognition receptor signalling
TL;DR: Accumulating evidence on how viral infection and PRR signalling pathways intersect is providing further insights into the function of the pathways involved, their constituent proteins and ways in which they could be manipulated therapeutically.
Journal ArticleDOI
Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor.
Tengchuan Jin,Andrew J. Perry,Jiansheng Jiang,Patrick F. Smith,James A. Curry,Leonie Unterholzner,Zhaozhao Jiang,Gabor Horvath,Vijay A. K. Rathinam,Ricky W. Johnstone,Ricky W. Johnstone,Veit Hornung,Eicke Latz,Eicke Latz,Andrew G. Bowie,Katherine A. Fitzgerald,T. Sam Xiao +16 more
TL;DR: These findings provide mechanistic insights into dsDNA as the activation trigger and oligomerization platform for the assembly of large innate signaling complexes such as the inflammasomes.
Journal ArticleDOI
Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage.
Gillian Dunphy,Sinead M. Flannery,Jessica F. Almine,Dympna J. Connolly,Christina Paulus,Kasper L Jønsson,Martin R. Jakobsen,Michael Nevels,Andrew G. Bowie,Leonie Unterholzner +9 more
TL;DR: It is found that keratinocytes and other human cells mount an innate immune response within hours of etoposide-induced DNA damage, which involves the DNA sensing adaptor STING but is independent of the cytosolic DNA receptor cGAS.
Journal ArticleDOI
SMG7 acts as a molecular link between mRNA surveillance and mRNA decay.
TL;DR: SMG7 provides a link between the NMD and the mRNA degradation machinery by interacting with SMG5 and UPF1 via its N-terminal domain and targeting bound transcripts for decay via its C-Terminal domain.