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Chih-Hung Hsu
Researcher at Harvard University
Publications - 4
Citations - 1229
Chih-Hung Hsu is an academic researcher from Harvard University. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 4, co-authored 4 publications receiving 901 citations. Previous affiliations of Chih-Hung Hsu include Boston Children's Hospital & Academia Sinica.
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Journal ArticleDOI
RNA m6A methylation regulates the ultraviolet-induced DNA damage response.
Yang Xiang,Benoit Laurent,Benoit Laurent,Chih-Hung Hsu,Chih-Hung Hsu,Sigrid Nachtergaele,Zhike Lu,Zhike Lu,Wanqiang Sheng,Wanqiang Sheng,Chuanyun Xu,Chuanyun Xu,Hao Chen,Hao Chen,Jian Ouyang,Siqing Wang,Siqing Wang,Siqing Wang,Dominic Ling,Dominic Ling,Pang-Hung Hsu,Lee Zou,Ashwini Jambhekar,Ashwini Jambhekar,Chuan He,Chuan He,Yang Shi,Yang Shi +27 more
TL;DR: It is reported that methylation at the 6 position of adenosine (m6A) in RNA is rapidly and transiently induced at DNA damage sites in response to ultraviolet irradiation, uncovering a novel function for RNA m6A modification in the ultraviolet-induced DNA damage response.
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DNA Methylation on N6-Adenine in C. elegans
Eric L. Greer,Eric L. Greer,Mario Andres Blanco,Mario Andres Blanco,Lei Gu,Lei Gu,Erdem Sendinc,Erdem Sendinc,Jianzhao Liu,David Aristizábal-Corrales,David Aristizábal-Corrales,Chih-Hung Hsu,Chih-Hung Hsu,L. Aravind,Chuan He,Yang Shi,Yang Shi +16 more
TL;DR: The presence of adenine N(6)-methylation (6mA) in C. elegans DNA is demonstrated and the exciting possibility that 6mA may be a carrier of heritable epigenetic information in eukaryotes is raised.
Journal ArticleDOI
The HPV E6 oncoprotein targets histone methyltransferases for modulating specific gene transcription.
Chih-Hung Hsu,K. L. Peng,K. L. Peng,H. C. Jhang,Chia-Hui Lin,Chia-Hui Lin,Chia-Hui Lin,Shwu Yuan Wu,Cheng Ming Chiang,Si-Chen Lee,W. C.Y. Yu,Li-Jung Juan,Li-Jung Juan,Li-Jung Juan +13 more
TL;DR: The results not only reveal a clever approach for the virus to interfere with p53 function, but also demonstrate the modulation of HMT activity as a novel mechanism of epigenetic regulation by a viral oncoprotein.
Journal ArticleDOI
Musashi-1 enhances glioblastoma cell migration and cytoskeletal dynamics through translational inhibition of Tensin3
Hsiao Yun Chen,Liang Ting Lin,Liang Ting Lin,Liang Ting Lin,Mong Lien Wang,Mong Lien Wang,Benoit Laurent,Chih-Hung Hsu,Chih-Hung Hsu,Chih Ming Pan,Chih Ming Pan,Wan Ru Jiang,Pau Yuan Chen,Hsin I. Ma,Yi Wei Chen,Yi Wei Chen,Pin I. Huang,Pin I. Huang,Arthur Chiou,Shih Hwa Chiou +19 more
TL;DR: It is reported that MSI1 alters cell morphology, promotes cell migration, and increases viscoelasticity of GBM cells, and a critical role of MSI1-TNS3 axis in regulating GBM migration is suggested.