C
Ching Yi Chen
Researcher at University of Alabama at Birmingham
Publications - 34
Citations - 3926
Ching Yi Chen is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: RNA-binding protein & Messenger RNA. The author has an hindex of 25, co-authored 32 publications receiving 3734 citations. Previous affiliations of Ching Yi Chen include University of California, San Diego & University of Vienna.
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Journal ArticleDOI
AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.
Ching Yi Chen,Roberto Gherzi,Shao En Ong,Edward L. Chan,Reinout Raijmakers,Ger J.M. Pruijn,Georg Stoecklin,Christoph Moroni,Matthias Mann,Michael Karin +9 more
TL;DR: Using a cell-free RNA decay system, it is demonstrated that the mammalian exosome is required for rapid degradation of ARE-containing RNAs but not for poly(A) shortening.
Journal ArticleDOI
A KH Domain RNA Binding Protein, KSRP, Promotes ARE-Directed mRNA Turnover by Recruiting the Degradation Machinery
Roberto Gherzi,Kyung Yeol Lee,Paola Briata,Daniel Wegmüller,Christoph Moroni,Michael Karin,Ching Yi Chen +6 more
TL;DR: It is demonstrated that KSRP, a KH domain-containing ARE-BP, is an essential factor for ARE-directed mRNA decay, which promotes rapid mRNA decay by recruiting degradation machinery to ARE-containing mRNAs.
Journal ArticleDOI
Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation
Ching Yi Chen,Roberto Gherzi,Jens S. Andersen,Guido M. Gaietta,Karsten Jürchott,Hans Dieter Royer,Matthias Mann,Michael Karin +7 more
TL;DR: Two major RNA-binding proteins, nucleolin and YB-1, are identified that specifically bind to the JNK response element in the 5' untranslated region (UTR) of interleukin-2 mRNA.
Journal ArticleDOI
Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway.
TL;DR: Signaling pathways that stabilize interleukin-2 (IL-2) messenger RNA (mRNA) in activated T cells were examined and multiple elements within IL-2 mRNA modulate its stability in a combinatorial manner.
Journal ArticleDOI
p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts.
Paola Briata,Sonia Vanina Forcales,Marco Ponassi,Giorgio Corte,Ching Yi Chen,Michael Karin,Pier Lorenzo Puri,Roberto Gherzi +7 more
TL;DR: It is demonstrated that p38 alpha and beta isoforms also control muscle-gene expression posttranscriptionally, by stabilizing critical myogenic transcripts, by establishing a biochemical link between differentiation-activated p38 signaling and turnover of myogenic mRNAs.