S
Sonia Vanina Forcales
Researcher at University of Barcelona
Publications - 22
Citations - 2205
Sonia Vanina Forcales is an academic researcher from University of Barcelona. The author has contributed to research in topics: Chromatin & Cellular differentiation. The author has an hindex of 13, co-authored 19 publications receiving 2026 citations. Previous affiliations of Sonia Vanina Forcales include Sanford-Burnham Institute for Medical Research & Sapienza University of Rome.
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Journal ArticleDOI
Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs
Changsung Kim,Johnson Wong,Jianyan Wen,Shirong Wang,Cheng Wang,Sean Spiering,Natalia G. Kan,Sonia Vanina Forcales,Pier Lorenzo Puri,Teresa C. Leone,Joseph E. Marine,Hugh Calkins,Daniel P. Kelly,Daniel P. Judge,Huei Sheng Vincent Chen,Huei Sheng Vincent Chen +15 more
TL;DR: This study is the first to demonstrate that induction of adult-like metabolism has a critical role in establishing an adult-onset disease model using patient-specific iPSCs, and revealed crucial pathogenic insights that metabolic derangement in adult- like metabolic milieu underlies ARVD/C pathologies, enabling us to propose novel disease-modifying therapeutic strategies.
Journal ArticleDOI
p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci.
Cristiano Simone,Sonia Vanina Forcales,David A. Hill,Anthony N. Imbalzano,Lucia Latella,Pier Lorenzo Puri +5 more
TL;DR: An unexpected function of differentiation-activated p38 is identified in converting external cues into chromatin modifications at discrete loci, by selectively targeting SWI-SNF to muscle-regulatory elements.
Journal ArticleDOI
TNF/p38α/Polycomb Signaling to Pax7 Locus in Satellite Cells Links Inflammation to the Epigenetic Control of Muscle Regeneration
Daniela Palacios,Chiara Mozzetta,Silvia Consalvi,Giuseppina Caretti,Giuseppina Caretti,Valentina Saccone,Valentina Proserpio,Valentina Proserpio,Victor E. Marquez,Sergio Valente,Antonello Mai,Sonia Vanina Forcales,Vittorio Sartorelli,Pier Lorenzo Puri +13 more
TL;DR: An inflammation-activated signaling in muscle stem (satellite) cells is identified, by which the polycomb repressive complex 2 (PRC2) represses Pax7 expression during muscle regeneration, establishing the biological link between p38/ PRC2 signaling to Pax7 and satellite cell decision to proliferate or differentiate.
Journal ArticleDOI
p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts.
Paola Briata,Sonia Vanina Forcales,Marco Ponassi,Giorgio Corte,Ching Yi Chen,Michael Karin,Pier Lorenzo Puri,Roberto Gherzi +7 more
TL;DR: It is demonstrated that p38 alpha and beta isoforms also control muscle-gene expression posttranscriptionally, by stabilizing critical myogenic transcripts, by establishing a biochemical link between differentiation-activated p38 signaling and turnover of myogenic mRNAs.
Journal ArticleDOI
Signal-dependent incorporation of MyoD-BAF60c into Brg1-based SWI/SNF chromatin-remodelling complex.
Sonia Vanina Forcales,Sonia Albini,Lorenzo Giordani,Barbora Malecova,Luca Cignolo,Andrei V. Chernov,Paula Coutinho,Valentina Saccone,Silvia Consalvi,Roy Steve Williams,Kepeng Wang,Zhenguo Wu,Svetlana Baranovskaya,Andrew M. Miller,F. Jeffrey Dilworth,Pier Lorenzo Puri +15 more
TL;DR: The data support an unprecedented two‐step model by which pre‐assembled BAF60c–MyoD complex directs recruitment of SWI/SNF to muscle loci in response to differentiation cues.