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Chris Boursnell
Researcher at University of Cambridge
Publications - 12
Citations - 15046
Chris Boursnell is an academic researcher from University of Cambridge. The author has contributed to research in topics: Breast cancer & Gene. The author has an hindex of 7, co-authored 11 publications receiving 14500 citations. Previous affiliations of Chris Boursnell include Wellcome Trust Sanger Institute.
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Journal ArticleDOI
Ancestral light and chloroplast regulation form the foundations for C4 gene expression.
Steven J. Burgess,Ignasi Granero-Moya,Mathieu J Grangé-Guermente,Chris Boursnell,Matthew J. Terry,Julian M. Hibberd +5 more
TL;DR: It is proposed that regulation of C4 cycle genes by light and the chloroplast in the ancestral C3 state has facilitated the repeated evolution of the complex and convergent C4 trait.
Journal ArticleDOI
Shared characteristics underpinning C4 leaf maturation derived from analysis of multiple C3 and C4 species of Flaveria
Britta M. C. Kümpers,Steven J. Burgess,Ivan Reyna-Llorens,Richard Smith-Unna,Chris Boursnell,Julian M. Hibberd +5 more
TL;DR: Principal components analysis indicated that leaf maturation and the photosynthetic pathway were responsible for the greatest amount of variation in transcript abundance, indicating that the complex C4 pathway is associated with parallel as well as convergent evolution.
Journal ArticleDOI
NRG1 fusions in breast cancer
Karen Howarth,Tashfina Mirza,Tashfina Mirza,Susanna L. Cooke,Suet-Feung Chin,Jessica C.M. Pole,Jessica C.M. Pole,Ernest Turro,Ernest Turro,Matthew D. Eldridge,Raquel Manzano Garcia,Oscar M. Rueda,Chris Boursnell,Jean Abraham,Jean Abraham,Carlos Caldas,Carlos Caldas,Paul A.W. Edwards +17 more
TL;DR: It is hypothesised that many NRG1 fusions may be oncogenic not for lacking the cytoplasmic domain but because they do not encodeNRG1’s nuclear-localised form, and confirmed that some do not activate but inactivate.
Imaging breast cancer using hyperpolarized carbon-13 MRI.
Ferdia A. Gallagher,Ramona Woitek,Ramona Woitek,Mary A. McLean,Andrew B. Gill,Raquel Manzano Garcia,Elena Provenzano,Frank Riemer,Joshua D. Kaggie,Anita Chhabra,Stephan Ursprung,James T. Grist,Charlie J. Daniels,Fulvio Zaccagna,Marie-Christine Laurent,Matthew Locke,Sarah Hilborne,Amy Frary,Turid Torheim,Chris Boursnell,Amy Schiller,Ilse Patterson,Rhys Slough,Bruno Carmo,Justine Kane,Heather Biggs,Emma Harrison,Surrin S. Deen,Andrew J. Patterson,Titus Lanz,Zoya Kingsbury,Mark T. Ross,Bristi Basu,Richard D. Baird,David J. Lomas,Evis Sala,James Wason,James Wason,Oscar M. Rueda,Suet-Feung Chin,Ian B. Wilkinson,Martin J. Graves,Jean Abraham,Fiona J. Gilbert,Carlos Caldas,Kevin M. Brindle +45 more
TL;DR: In this paper, the feasibility of imaging tumor metabolism in breast cancer patients using 13C magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized 13C label exchange between injected [1-13C]pyruvate and the endogenous tumor lactate pool was investigated.
Posted ContentDOI
Shared characteristics underpinning C4 leaf maturation derived from analysis of multiple C3 and C4 species of Flaveria
Britta M. C. Kümpers,Steven J. Burgess,Ivan Reyna-Llorens,Richard Smith-Unna,Chris Boursnell,Julian M. Hibberd +5 more
TL;DR: Principal Components Analysis indicated that leaf maturation and then photosynthetic pathway were responsible for the greatest amount of variation in transcript abundance, indicating that the complex C4 pathway is associated with parallel as well as convergent evolution.