F
Frank Riemer
Researcher at University of Cambridge
Publications - 48
Citations - 978
Frank Riemer is an academic researcher from University of Cambridge. The author has contributed to research in topics: Medicine & Magnetic resonance imaging. The author has an hindex of 11, co-authored 35 publications receiving 509 citations. Previous affiliations of Frank Riemer include Haukeland University Hospital & UCL Institute of Neurology.
Papers
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Journal ArticleDOI
Quantifying normal human brain metabolism using hyperpolarized [1-13C]pyruvate and magnetic resonance imaging.
James T. Grist,Mary A. McLean,Frank Riemer,Rolf F. Schulte,Surrin S. Deen,Fulvio Zaccagna,Ramona Woitek,Charlie J. Daniels,Joshua D. Kaggie,Tomasz Matys,Ilse Patterson,Rhys Slough,Andrew B. Gill,Anita Chhabra,Rose Eichenberger,Marie-Christine Laurent,Arnaud Comment,Jonathan H. Gillard,Alasdair Coles,Damian J. Tyler,Ian B. Wilkinson,Bristi Basu,David J. Lomas,Martin J. Graves,Kevin M. Brindle,Ferdia A. Gallagher +25 more
TL;DR: Imaging normal brain metabolism with hyperpolarized [1–13C]pyruvate and subsequent quantification, have important implications for interpreting pathological cerebral metabolism in future studies.
Journal ArticleDOI
Imaging breast cancer using hyperpolarized carbon-13 MRI.
Ferdia A. Gallagher,Ramona Woitek,Ramona Woitek,Mary A. McLean,Andrew B. Gill,Raquel Manzano Garcia,Elena Provenzano,Frank Riemer,Joshua D. Kaggie,Anita Chhabra,Stephan Ursprung,James T. Grist,Charlie J. Daniels,Fulvio Zaccagna,Marie-Christine Laurent,Matthew Locke,Sarah Hilborne,Amy Frary,Turid Torheim,Chris Boursnell,Amy Schiller,Ilse Patterson,Rhys Slough,Bruno Carmo,Justine Kane,Heather Biggs,Emma Harrison,Surrin S. Deen,Andrew J. Patterson,Titus Lanz,Zoya Kingsbury,Mark T. Ross,Bristi Basu,Richard D. Baird,David J. Lomas,Evis Sala,James Wason,James Wason,Oscar M. Rueda,Suet-Feung Chin,Ian B. Wilkinson,Martin J. Graves,Jean Abraham,Fiona J. Gilbert,Carlos Caldas,Kevin M. Brindle +45 more
TL;DR: Imaging of hyperpolarized [1-13C]pyruvate metabolism in breast cancer is feasible and demonstrated significant intertumoral and intratumoral metabolic heterogeneity, where lactate labeling correlated with MCT1 expression and hypoxia.
Journal ArticleDOI
Sodium accumulation is associated with disability and a progressive course in multiple sclerosis
David Paling,Bhavana Solanky,Frank Riemer,Daniel J. Tozer,Claudia A. M. Wheeler-Kingshott,Raju Kapoor,Xavier Golay,David Miller +7 more
TL;DR: Sodium concentration is increased within lesions, normal appearing white matter and cortical and deep grey matter in multiple sclerosis, with higher concentrations seen in secondary-progressive multiple sclerosis and in patients with greater disability.
Journal ArticleDOI
Sodium homeostasis in the tumour microenvironment.
Theresa K. Leslie,Andrew D. James,Fulvio Zaccagna,James T. Grist,Surrin S. Deen,Aneurin J. Kennerley,Frank Riemer,Joshua D. Kaggie,Ferdia A. Gallagher,Fiona J. Gilbert,William J. Brackenbury +10 more
TL;DR: Evidence indicating that Na+ handling is altered in tumours is reviewed, the current understanding of the mechanisms that may underlie these alterations are explored and the potential consequences for cancer progression are considered.
Journal ArticleDOI
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease.
Brage Brakedal,Christian Dölle,Frank Riemer,Yilong Ma,Gonzalo S. Nido,Geir Olve Skeie,Alexander R. Craven,Thomas Schwarzlmüller,Njål Brekke,Joseph Diab,Lars Jansen Sverkeli,Vivian Skjeie,K. Varhaug,Ole-Bjørn Tysnes,Shichun Peng,Kristoffer Haugarvoll,Mathias Ziegler,Renate Grüner,David Eidelberg,Charalampos Tzoulis +19 more
TL;DR: In this paper , the authors conducted a double-blinded phase I clinical trial to establish whether nicotinamide adenine dinucleotide (NAD) replenishment therapy via oral intake of Nicotinamide riboside (NR), is safe, augments cerebral NAD levels, and impacts cerebral metabolism in Parkinson's disease (PD).