Charlie J. Daniels

TL;DR: Imaging normal brain metabolism with hyperpolarized [1–13C]pyruvate and subsequent quantification, have important implications for interpreting pathological cerebral metabolism in future studies.

TL;DR: Imaging of hyperpolarized [1-13C]pyruvate metabolism in breast cancer is feasible and demonstrated significant intertumoral and intratumoral metabolic heterogeneity, where lactate labeling correlated with MCT1 expression and hypoxia.

TL;DR: In this study, an in vitro system was used to compare several kinetic models, as well as simple model‐free methods, and appropriate quantitative methods were identified for future work in the analysis of human hyperpolarized 13C data.

TL;DR: A spatially explicit mathematical model with a modular framework that enables different potential mechanisms to be turned on and off in order to adjust specific tumor and tissue interactions to match a specific patient's disease and proposes hypotheses about the underlying resistance mechanisms.

TL;DR: Hyperpolarized 13C MRI demonstrated variation in lactate labeling in GBM, both within and between tumors, and bicarbonate labeling was consistently lower in tumors than in the surrounding NABP.