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Ernest Turro
Researcher at University of Cambridge
Publications - 79
Citations - 4968
Ernest Turro is an academic researcher from University of Cambridge. The author has contributed to research in topics: Gene & Platelet disorder. The author has an hindex of 32, co-authored 76 publications receiving 3830 citations. Previous affiliations of Ernest Turro include Icahn School of Medicine at Mount Sinai & NHS Blood and Transplant.
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Journal ArticleDOI
The Human Phenotype Ontology in 2017
Sebastian Köhler,Nicole Vasilevsky,Mark Engelstad,Erin D. Foster,Julie A. McMurry,Ségolène Aymé,Gareth Baynam,Gareth Baynam,Susan M. Bello,Cornelius F. Boerkoel,Kym M. Boycott,Michael Brudno,Orion J. Buske,Patrick F. Chinnery,Valentina Cipriani,Laureen E. Connell,Hugh Dawkins,Laura E. DeMare,Andrew D. Devereau,Bert B.A. de Vries,Helen V. Firth,Kathleen Freson,Daniel Greene,Ada Hamosh,Ingo Helbig,Ingo Helbig,Courtney Hum,Johanna A. Jähn,Roger James,Roland Krause,Stanley J. F. Laulederkind,Hanns Lochmüller,Gholson J. Lyon,Soichi Ogishima,Annie Olry,Willem H. Ouwehand,Nikolas Pontikos,Ana Rath,Franz Schaefer,Richard H. Scott,Michael M. Segal,Panagiotis I. Sergouniotis,Richard Sever,Cynthia L. Smith,Volker Straub,Rachel Thompson,C. Turner,Ernest Turro,Marijcke W. M. Veltman,Tom Vulliamy,Jing Yu,Julie von Ziegenweidt,Andreas Zankl,Stephan Züchner,Tomasz Zemojtel,Julius O.B. Jacobsen,Tudor Groza,Damian Smedley,Christopher J. Mungall,Melissa A. Haendel,Peter N. Robinson +60 more
TL;DR: The progress of the HPO project is reviewed, including specific areas of expansion such as common (complex) disease, new algorithms for phenotype driven genomic discovery and diagnostics, integration of cross-species mapping efforts with the Mammalian Phenotype Ontology, an improved quality control pipeline, and the addition of patient-friendly terminology.
Journal ArticleDOI
Haplotype and isoform specific expression estimation using multi-mapping RNA-seq reads
TL;DR: A new statistical method, MMSEQ, deconvolves the mapping of reads to multiple transcripts (isoforms or haplotype-specific isoforms) and can take into account non-uniform read generation and works with paired-end reads.
Journal ArticleDOI
Whole-genome sequencing of patients with rare diseases in a national health system.
Ernest Turro,William J. Astle,William J. Astle,Karyn Megy,Stefan Gräf,Daniel Greene,Olga Shamardina,Hana Lango Allen,Alba Sanchis-Juan,Mattia Frontini,Mattia Frontini,Mattia Frontini,Chantal Thys,Jonathan Stephens,Rutendo Mapeta,Oliver S. Burren,Kate Downes,Matthias Haimel,Salih Tuna,Deevi Svv.,Timothy J. Aitman,Timothy J. Aitman,David L.H. Bennett,David L.H. Bennett,P Calleja,Keren J. Carss,Mark J. Caulfield,Patrick F. Chinnery,Peter H. Dixon,Daniel P. Gale,Rachael H. James,Ania Koziell,Ania Koziell,Michael Laffan,Michael Laffan,Adam P. Levine,Eamonn R. Maher,Hugh S. Markus,Joannella Morales,Nicholas W. Morrell,Andrew D Mumford,Andrew D Mumford,Elizabeth Ormondroyd,S Rankin,Augusto Rendon,Sylvia Richardson,Irene Roberts,Roy Nba.,M A Saleem,M A Saleem,Smith Kgc.,Hannah Stark,Tan Ryy.,Andreas C. Themistocleous,Adrian J. Thrasher,Hugh Watkins,Andrew R. Webster,Andrew R. Webster,Martin R. Wilkins,Catherine Williamson,Catherine Williamson,James A. G. Whitworth,Sean Humphray,David R. Bentley,Nathalie Kingston,Neil Walker,John Bradley,Sofie Ashford,Christopher J. Penkett,Kathleen Freson,Kathleen Stirrups,F. Lucy Raymond,Willem H. Ouwehand +72 more
TL;DR: This study used whole-genome sequencing in a national health system to streamline diagnosis and to discover unknown aetiological variants in the coding and non-coding regions of the genome, finding that rare alleles can explain the presence of some individuals in the tails of a quantitative trait for red blood cells.
Journal ArticleDOI
Transcriptional diversity during lineage commitment of human blood progenitors
Lu Chen,Lu Chen,Lu Chen,Myrto Kostadima,Myrto Kostadima,Myrto Kostadima,Joost H.A. Martens,Giovanni Canu,Giovanni Canu,Sara P. Garcia,Sara P. Garcia,Ernest Turro,Ernest Turro,Kate Downes,Kate Downes,Iain C. Macaulay,Ewa Bielczyk-Maczyńska,Ewa Bielczyk-Maczyńska,Sophia Coe,Sophia Coe,Samantha Farrow,Samantha Farrow,Pawan Poudel,Pawan Poudel,Frances Burden,Frances Burden,Sjoert B. G. Jansen,Sjoert B. G. Jansen,William J. Astle,William J. Astle,Antony P. Attwood,Antony P. Attwood,Tadbir K. Bariana,Bernard de Bono,Bernard de Bono,Alessandra Breschi,John C. Chambers,John C. Chambers,Fizzah A. Choudry,Fizzah A. Choudry,Laura Clarke,Paul Coupland,Martijn van der Ent,Wendy N. Erber,Joop H. Jansen,Rémi Favier,Matthew Fenech,Nicola Foad,Nicola Foad,Kathleen Freson,Chris Van Geet,Keith Gomez,Roderic Guigó,Daniel Hampshire,Daniel Hampshire,Anne M. Kelly,Anne M. Kelly,Anne M. Kelly,Hindrik H. D. Kerstens,Jaspal S. Kooner,Jaspal S. Kooner,Michael Laffan,Claire Lentaigne,Charlotte Labalette,Charlotte Labalette,Tiphaine Martin,Tiphaine Martin,Tiphaine Martin,Stuart Meacham,Stuart Meacham,Andrew D Mumford,Sylvia T. Nurnberg,Sylvia T. Nurnberg,Emilio Palumbo,Bert A. van der Reijden,David J. Richardson,Stephen John Sammut,Greg Slodkowicz,Asif U. Tamuri,Louella Vasquez,Katrin Voss,Katrin Voss,Stephen Watt,Sarah K Westbury,Paul Flicek,Paul Flicek,Remco Loos,Nick Goldman,Paul Bertone,Paul Bertone,Randy J. Read,Sylvia Richardson,Ana Cvejic,Ana Cvejic,Nicole Soranzo,Nicole Soranzo,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Hendrik G. Stunnenberg,Mattia Frontini,Mattia Frontini,Augusto Rendon,Augusto Rendon +103 more
TL;DR: A previously undetected layer of regulation affecting cell fating is unveiled, which involves transcriptional isoforms switching without noticeable changes at the gene level and resulting in the gain or loss of protein functions in blood cells involved in the immune system.
Supplementary resources_Transcriptional diversity during lineage commitment of human blood progenitors
Lu Chen,Myrto Kostadima,Joost H.A. Martens,Giovanni Canu,Sara P. Garcia,Ernest Turro,Kate Downes,Iain C. Macaulay,E. Bielczyk Maczynska,S. Coe,Samantha Farrow,Pawan Poudel,Frances Burden,Sjoert B. G. Jansen,William J. Astle,Antony P. Attwood,Tadbir K. Bariana,B. de Bono,Alessandra Breschi,John C. Chambers,Fizzah A. Choudry,Laura Clarke,Paul Coupland,M. van der Ent,Wendy N. Erber,Joop H. Jansen,Rémi Favier,Matthew Fenech,Nicola Foad,Kathleen Freson,C. van Geet,Keith Gomez,Roderic Guigó,D. Hampshire,Anne M. Kelly,Hindrik H. D. Kerstens,Jaspal S. Kooner,Michael Laffan,Claire Lentaigne,Charlotte Labalette,Tiphaine Martin,Stuart Meacham,Andrew D Mumford,Sylvia T. Nurnberg,Emilio Palumbo,B. A. van der Reijden,David J. Richardson,Stephen John Sammut,Greg Slodkowicz,Asif U. Tamuri,Louella Vasquez,Katrin Voss,Stephen Watt,Sarah K Westbury,Paul Flicek,Remco Loos,Nick Goldman,P. Bertone,Randy J. Read,Sylvia Richardson,Ana Cvejic,Nicole Soranzo,Willem H. Ouwehand,Hendrik G. Stunnenberg,Mattia Frontini,Augusto Rendon +65 more