Topological photonics is a rapidly emerging field of research in which geometrical and topological ideas are exploited to design and control the behavior of light. Drawing inspiration from the discovery of the quantum Hall effects and topological insulators in condensed matter, recent advances have shown how to engineer analogous effects also for photons, leading to remarkable phenomena such as the robust unidirectional propagation of light, which hold great promise for applications. Thanks to the flexibility and diversity of photonics systems, this field is also opening up new opportunities to realize exotic topological models and to probe and exploit topological effects in new ways. This article reviews experimental and theoretical developments in topological photonics across a wide range of experimental platforms, including photonic crystals, waveguides, metamaterials, cavities, optomechanics, silicon photonics, and circuit QED. A discussion of how changing the dimensionality and symmetries of photonics systems has allowed for the realization of different topological phases is offered, and progress in understanding the interplay of topology with non-Hermitian effects, such as dissipation, is reviewed. As an exciting perspective, topological photonics can be combined with optical nonlinearities, leading toward new collective phenomena and novel strongly correlated states of light, such as an analog of the fractional quantum Hall effect.

Topological Photonics

The PANTHER (protein annotation through evolutionary relationship) classification system (http://wwwpantherdborg/) is a comprehensive system that combines gene function, ontology, pathways and statistical analysis tools that enable biologists to analyze large-scale, genome-wide data from sequencing, proteomics or gene expression experiments The system is built with 82 complete genomes organized into gene families and subfamilies, and their evolutionary relationships are captured in phylogenetic trees, multiple sequence alignments and statistical models (hidden Markov models or HMMs) Genes are classified according to their function in several different ways: families and subfamilies are annotated with ontology terms (Gene Ontology (GO) and PANTHER protein class), and sequences are assigned to PANTHER pathways The PANTHER website includes a suite of tools that enable users to browse and query gene functions, and to analyze large-scale experimental data with a number of statistical tests It is widely used by bench scientists, bioinformaticians, computer scientists and systems biologists In the 2013 release of PANTHER (v80), in addition to an update of the data content, we redesigned the website interface to improve both user experience and the system's analytical capability This protocol provides a detailed description of how to analyze genome-wide experimental data with the PANTHER classification system

Large-scale gene function analysis with the PANTHER classification system

A detailed review of the education sector in Australia as in the data provided by the 2006 edition of the OECD's annual publication, 'Education at a Glance' is presented. While the data has shown that in almost all OECD countries educational attainment levels are on the rise, with countries showing impressive gains in university qualifications, it also reveals that a large of share of young people still do not complete secondary school, which remains a baseline for successful entry into the labour market.

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Education at a Glance

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Applied Missing Data Analysis

The data and tools in PANTHER—a comprehensive, curated database of protein families, trees, subfamilies and functions available at http://pantherdb.org—have undergone continual, extensive improvement for over a decade. Here, we describe the current PANTHER process as a whole, as well as the website tools for analysis of user-uploaded data. The main goals of PANTHER remain essentially unchanged: the accurate inference (and practical application) of gene and protein function over large sequence databases, using phylogenetic trees to extrapolate from the relatively sparse experimental information from a few model organisms. Yet the focus of PANTHER has continually shifted toward more accurate and detailed representations of evolutionary events in gene family histories. The trees are now designed to represent gene family evolution, including inference of evolutionary events, such as speciation and gene duplication. Subfamilies are still curated and used to define HMMs, but gene ontology functional annotations can now be made at any node in the tree, and are designed to represent gain and loss of function by ancestral genes during evolution. Finally, PANTHER now includes stable database identifiers for inferred ancestral genes, which are used to associate inferred gene attributes with particular genes in the common ancestral genomes of extant species.

PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees

The central nervous system of Drosophila melanogaster consists of fused segmental units (neuromeres), each generated by a characteristic number of neural stem cells (neuroblasts). In the embryo, thoracic and anterior abdominal neuromeres are almost equally sized and formed by repetitive sets of neuroblasts, whereas the terminal abdominal neuromeres are generated by significantly smaller populations of progenitor cells. Here we investigated the role of the Hox gene Abdominal-B in shaping the terminal neuromeres. We show that the regulatory isoform of Abdominal-B (Abd-B.r) not only confers abdominal fate to specific neuroblasts (e.g. NB6-4) and regulates programmed cell death of several progeny cells within certain neuroblast lineages (e.g. NB3-3) in parasegment 14, but also inhibits the formation of a specific set of neuroblasts in parasegment 15 (including NB7-3). We further show that Abd-B.r requires cooperation of the ParaHox gene caudal to unfold its full competence concerning neuroblast inhibition and specification. Thus, our findings demonstrate that combined action of Abdominal-B and caudal contributes to the size and composition of the terminal neuromeres by regulating both the number and lineages of specific neuroblasts.

Abdominal-B and caudal inhibit the formation of specific neuroblasts in the Drosophila tail region

We describe the fabrication and characterisation of a touch-mode capacitive pressure sensor (TMCPS) with a robust design that comprises a graphene-polymer heterostructure film, laminated onto the silicon dioxide surface of a silicon wafer, incorporating a SU-8 spacer grid structure. The spacer grid structure allows the flexible graphene-polymer film to be partially suspended above the substrate, such that a pressure on the membrane results in a reproducible deflection, even after exposing the membrane to pressures over 10 times the operating range. Sensors show reproducible pressure transduction in water submersion at varying depths under static and dynamic loading. The measured capacitance change in response to pressure is in good agreement with an analytical model of clamped plates in touch mode. The device shows a pressure sensitivity of 27.1 0.5 fF Pa−1 over a pressure range of 0.5 kPa–8.5 kPa. In addition, we demonstrate the operation of this device as a force-touch sensor in air.

https://iopscience.iop.org/article/10.1088/2053-1583/aa8c8a/pdf

Touch-mode capacitive pressure sensor with graphene-polymer heterostructure membrane

El presente trabajo describe un programa para favorecer el bienestar y aprendizaje socioemocional en estudiantes de tercer y cuarto ano de Ensenanza General Basica, y su evaluacion de impacto. Los fundamentos conceptuales del programa para el Bienestar y Aprendizaje Socioemocional se apoyan en la perspectiva del aprendizaje socioemocional, que integra factores tanto en el ambito individual como del contexto. El programa enfatiza el desarrollo de vinculos interpersonales de calidad y el desarrollo de las competencias necesarias para ello. A traves de un diseno cuasiexperimental que incluyo a 647 estudiantes de tercero y cuarto grado en cinco colegios particulares subvencionados de Santiago, Chile, la evaluacion con analisis de la varianza de medidas repetidas mostro un impacto del programa en la autoestima de los estudiantes percibida por sus profesores (medida a traves del test de autoestima). Asimismo, el programa mitigo el descenso en la percepcion del clima escolar segun la Escala de Clima Social, en indicadores de integracion social, y en el rendimiento escolar, que se observo en el grupo control. Se discuten los resultados del programa y sus posibles implicancias para el desarrollo de intervenciones en este campo

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Programa para el Bienestar y Aprendizaje Socioemocional en estudiantes de tercero y cuarto grado: descripción y evaluación de impacto

Underwater acoustic channels induce large Doppler drifts that render intercarrier interference (ICI) for OFDM transmissions. Assuming that after proper Doppler compensation the residual ICI is limited to only direct neighbors, we propose an OFDM signal design that decouples channel estimation and data demodulation. We investigate eight receivers that are categorized into three groups: (i) three receivers that ignore the residual ICI, (ii) three receivers that are based on a basis expansion model (BEM) and pursue channel estimation independently along each basis, and (iii) two receivers that are based on discrete-path modeling. The receiver performance is compared based on data from the SPACE experiment conducted off the coast of Martha's Vineyard, Massachusetts, October 2008. The receiver based on the discrete-path modeling and a basis pursuit algorithm achieves the best performance while the receiver based on BEM and least-squares channel estimation performs the worst. The performance differences among different receivers drastically increase as the channel's Doppler spread and the signal constellation size increase. Interestingly, the BEM based receivers are often inferior to the ICI-ignorant counterparts, implying that the ability of ICI compensation could be limited by the estimation accuracy of the much increased number of model parameters.

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Receiver comparisons on an OFDM design for Doppler spread channels

Semiconductor laser characteristics based on type-II band-aligned quantum well heterostructures for the emission at 1.2 μm are presented. Ten “W”-quantum wells consisting of GaAs/(GaIn)As/Ga(AsSb)/(GaIn)As/GaAs are arranged as resonant periodic gain in a vertical-external-cavity surface-emitting laser. Its structure is analyzed by X-ray diffraction, photoluminescence, and reflectance measurements. The laser's power curves and spectra are investigated. Output powers at Watt level are achieved, with a maximum output power of 4 W. It is confirmed that laser operation only involves the type-II transition. A blue shift of the material gain is observed while the modal gain exhibits a red shift.

Christian Berger

Papers

Abdominal-B and caudal inhibit the formation of specific neuroblasts in the Drosophila tail region

Touch-mode capacitive pressure sensor with graphene-polymer heterostructure membrane

Programa para el Bienestar y Aprendizaje Socioemocional en estudiantes de tercero y cuarto grado: descripción y evaluación de impacto

Receiver comparisons on an OFDM design for Doppler spread channels

Type-II vertical-external-cavity surface-emitting laser with Watt level output powers at 1.2 μm