Showing papers by "Christian Laurent published in 2006"
TL;DR: Patients starting HAART in resource-poor settings have increased mortality rates in the first months on therapy, compared with those in developed countries, and timely diagnosis and assessment of treatment eligibility, coupled with free provision of HAART might reduce this excess mortality.
1,143 citations
TL;DR: This study underlines the early mortality pattern after HAART initiation and highlights the leading role of mycobacterial infections in the causes of death.
Abstract: The objectives were to evaluate survival and investigate causes of death among HIV-1 infected adults receiving HAART in Senegal. Design: An observational prospective cohort. Methods: Mortality was assessed in the first patients enrolled between August 1998 and April 2002 in the Senegalese antiretroviral drug access initiative. First-line regimen combined two nucleoside reverse transcriptase inhibitors and either a non-nucleoside reverse transcriptase inhibitor or a protease inhibitor. The most likely causes of death were ascertained through medical records or post-mortem interviews (verbal autopsy). Four hundred and four patients (54.7% women) were enrolled in the study and were followed for a median of 46 months (interquartile range: 32-57 months) after HAART initiation. At baseline 5% were antiretroviral therapy (ART) non-naive 39 and 55% were respectively at CDC stage B and C median age CD4 cell count and viral load were 37 years 128 cells/ml and 5.2 log cp/ml respectively. Ninety-three patients died during follow-up and the overall incidence rate of death was 6.3/100 person-years [95% confidence interval (CI) 5.2-7.7]. During the first year after HAART initiation 47 patients died and seven were lost to follow-up yielding to a probability of dying of 11.7% (95% CI 8.9-15.3%). The death rate which was highest during the first year after HAART initiation decreased with time yielding a cumulative probability of dying of 17.4% (95% CI 13.9-21.5%) and 24.6% (95% CI 20.4-29.4%) at 2 and 5 years. Causes of death were ascertained in 76 deaths. Mycobacterial infections neurotropic infections and septicaemia were the most frequent likely causes of death. This study underlines the early mortality pattern after HAART initiation and highlights the leading role of mycobacterial infections in the causes of death. (authors)
276 citations
TL;DR: Whether mutations associated with resistance to antiretroviral (ARV) drugs circulate among treatment-naive HIV-1-infected individuals at a period when these drugs started to become more widely available in Africa is analysed.
Abstract: We analysed whether mutations associated with resistance to antiretroviral (ARV) drugs circulate among treatment-naive HIV-1-infected individuals at a period when these drugs started to become more...
63 citations
TL;DR: The development and validation of sensitive and specific SIV antibody detection assays representing all major known primate lentiviral lineages on a panel of 207 sera from 11 different primate species with known infection status were described and used to determine SIV prevalence rates in nine primates native to Cameroon.
52 citations
TL;DR: Among 128 patients routinely receiving highly active antiretroviral therapy in an HIV/AIDS outpatient clinic in Cameroon, 16.4% had drug resistance after a median of 10 months.
Abstract: Among 128 patients routinely receiving highly active antiretroviral therapy in an HIV/AIDS outpatient clinic in Cameroon, 16.4% had drug resistance after a median of 10 months. Of these, 12.5% had resistance to nucleoside reverse transcriptase inhibitors (NRTIs), 10.2% to non-NRTIs, and 2.3% to protease inhibitors.
34 citations
07 Aug 2006
5 citations