Martin Mueller-Zsigmondy

TL;DR: This study presents a meta-analysis of the phytochemical properties of seven novel drugs that have been developed over a period of several years and show promise in terms of protecting against adverse events and promoting drug safety.

TL;DR: Flow-through method was confirmed as the most appropriate for accelerated in vitro dissolution testing for a given formulation for peptide loaded PLGA microspheres using flow-through apparatus and assessment of the effect of dissolution parameters on drug release rate and mechanism.

TL;DR: Lack of restrictions on ribociclib dosing may facilitate better patient compliance and therefore clinical benefit, and no impact of gastric pH‐altering agents on the absorption of ribocIClib is stated, without a dedicated drug–drug interaction trial.

TL;DR: There was a trend towards a higher appreciation of the BCS among the regulators, but a less positive attitude towards the utility of non‐compendial dissolution methods for establishing a successful IVIVC/IVIVIVR.

TL;DR: In this paper, the authors report five case studies on using PBBM to establish a safe space for BCS Class 2 and 4 across different companies, including applications in an industrial setting for both internal decision making or regulatory applications.