C
Christian R. Lee
Researcher at Rutgers University
Publications - 33
Citations - 1577
Christian R. Lee is an academic researcher from Rutgers University. The author has contributed to research in topics: Substantia nigra & Medium spiny neuron. The author has an hindex of 15, co-authored 32 publications receiving 1306 citations. Previous affiliations of Christian R. Lee include New York University & Hungarian Academy of Sciences.
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Book ChapterDOI
GABAergic control of substantia nigra dopaminergic neurons
James M. Tepper,Christian R. Lee +1 more
TL;DR: In addition to the effects that nigral GABAergic output neurons have on their target nuclei outside of the basal ganglia, local interactions between GABAergic projection neurons and dopaminergic neurons are crucially important to the functioning of the nigral dopaminationergic neurons.
Journal ArticleDOI
Aberrant Cortical Activity in Multiple GCaMP6-Expressing Transgenic Mouse Lines.
Nicholas A. Steinmetz,Nicholas A. Steinmetz,Christina Buetfering,Jérôme Lecoq,Christian R. Lee,Andrew J. Peters,Elina A. K. Jacobs,Philip Coen,Douglas R. Ollerenshaw,Matthew T. Valley,Saskia E. J. de Vries,Marina Garrett,Jun Zhuang,Peter A. Groblewski,Sahar Manavi,Jesse Miles,Casey White,Eric Lee,Fiona Griffin,Joshua D. Larkin,Kate Roll,Sissy Cross,Thuyanh V. Nguyen,Rachael Larsen,Julie Pendergraft,Tanya L. Daigle,Bosiljka Tasic,Carol L. Thompson,Jack Waters,Shawn R. Olsen,David J. Margolis,Hongkui Zeng,Michael Häusser,Matteo Carandini,Kenneth D. Harris +34 more
TL;DR: Aberrant electrical activity, similar to interictal spikes, and accompanying fluorescence events in some genotypes of transgenic mice expressing GCaMP6 genetically encoded calcium sensors are reported, observed particularly in mice with Emx1-Cre and Ai93 transgenes across multiple laboratories.
Journal ArticleDOI
Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward
Melissa A. Stouffer,Catherine Woods,Jyoti C. Patel,Christian R. Lee,Paul Witkovsky,Li Bao,Robert Machold,Kymry T. Jones,Soledad Cabeza de Vaca,Maarten E. A. Reith,Kenneth D. Carr,Margaret E. Rice +11 more
TL;DR: It is reported here that insulin can amplify action potential-dependent dopamine release in the nucleus accumbens (NAc) and caudate–putamen through an indirect mechanism that involves striatal cholinergic interneurons that express InsRs.
Journal ArticleDOI
Cell Type-Specific Differences in Chloride-Regulatory Mechanisms and GABAA Receptor-Mediated Inhibition in Rat Substantia Nigra
Alexandra Gulácsi,Christian R. Lee,Attila Sik,Tero Viitanen,Kai Kaila,James M. Tepper,Tamás F. Freund +6 more
TL;DR: It is suggested that KCC2 is responsible for maintaining the low intracellular Cl- concentration in nigral GABAergic neurons, whereas a sodium-dependent anion (Cl--HCO3-) exchanger and ClC-2 are likely to serve this role in dopaminergic neurons.
Journal ArticleDOI
Mitochondria Are the Source of Hydrogen Peroxide for Dynamic Brain-Cell Signaling
Li Bao,Marat V. Avshalumov,Jyoti C. Patel,Christian R. Lee,Evan W. Miller,Christopher J. Chang,Margaret E. Rice +6 more
TL;DR: In this article, the authors investigated three possible sources of H2O2 produced for rapid neuronal signaling in striatum: mitochondrial respiration, monoamine oxidase (MAO), and NADPH oxidase(Nox).