R
Rachael Larsen
Researcher at Allen Institute for Brain Science
Publications - 18
Citations - 3197
Rachael Larsen is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Neocortex & Visual cortex. The author has an hindex of 12, co-authored 18 publications receiving 1709 citations. Previous affiliations of Rachael Larsen include Allen Institute for Artificial Intelligence.
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Journal ArticleDOI
Shared and distinct transcriptomic cell types across neocortical areas
Bosiljka Tasic,Zizhen Yao,Lucas T. Graybuck,Kimberly A. Smith,Thuc Nghi Nguyen,Darren Bertagnolli,Jeff Goldy,Emma Garren,Michael N. Economo,Sarada Viswanathan,Osnat Penn,Trygve E. Bakken,Vilas Menon,Vilas Menon,Jeremy A. Miller,Olivia Fong,Karla E. Hirokawa,Kanan Lathia,Christine Rimorin,Michael Tieu,Rachael Larsen,Tamara Casper,Eliza Barkan,Matthew Kroll,Sheana Parry,Nadiya V. Shapovalova,Daniel Hirschstein,Julie Pendergraft,Heather A. Sullivan,Tae Kyung Kim,Aaron Szafer,Nick Dee,Peter A. Groblewski,Ian R. Wickersham,Ali Cetin,Julie A. Harris,Boaz P. Levi,Susan M. Sunkin,Linda Madisen,Tanya L. Daigle,Loren L. Looger,Amy Bernard,John W. Phillips,Ed S. Lein,Michael Hawrylycz,Karel Svoboda,Allan R. Jones,Christof Koch,Hongkui Zeng +48 more
TL;DR: This study establishes a combined transcriptomic and projectional taxonomy of cortical cell types from functionally distinct areas of the adult mouse cortex and identifies 133 transcriptomic types of glutamatergic neurons to their long-range projection specificity.
Journal ArticleDOI
A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality
Tanya L. Daigle,Linda Madisen,Travis A. Hage,Matthew T. Valley,Ulf Knoblich,Rylan S. Larsen,Marc Takeno,Lawrence Huang,Hong Gu,Rachael Larsen,Maya Mills,Alice Bosma-Moody,La'Akea Siverts,Miranda Walker,Lucas T. Graybuck,Zizhen Yao,Olivia Fong,Thuc Nghi Nguyen,Emma Garren,Garreck H. Lenz,Mariya Chavarha,Julie Pendergraft,James Harrington,Karla E. Hirokawa,Julie A. Harris,Philip R. Nicovich,Medea McGraw,Douglas R. Ollerenshaw,Kimberly A. Smith,Christopher A. Baker,Jonathan T. Ting,Susan M. Sunkin,Jérôme Lecoq,Michael Z. Lin,Edward S. Boyden,Gabe J. Murphy,Nuno Maçarico da Costa,Jack Waters,Lu Li,Bosiljka Tasic,Hongkui Zeng +40 more
TL;DR: A large set of driver and reporter transgenic mouse lines are reported, including 23 new driver lines targeting a variety of cortical and subcortical cell populations and 26 new reporter lines expressing an array of molecular tools.
Posted ContentDOI
Shared and distinct transcriptomic cell types across neocortical areas
Bosiljka Tasic,Zizhen Yao,Kimberly A. Smith,Lucas T. Graybuck,Thuc Nghi Nguyen,Darren Bertagnolli,Jeff Goldy,Emma Garren,Michael N. Economo,Sarada Viswanathan,Osnat Penn,Trygve E. Bakken,Vilas Menon,Jeremy A. Miller,Olivia Fong,Karla E. Hirokawa,Kanan Lathia,Christine Rimorin,Michael Tieu,Rachael Larsen,Tamara Casper,Eliza Barkan,Matthew Kroll,Seana Parry,Nadiya V. Shapovalova,Daniel Hirschstein,Julie Pendergraft,Tae Kyung Kim,Aaron Szafer,Nick Dee,Peter A. Groblewski,Ian R. Wickersham,Ali Cetin,Julie A. Harris,Boaz P. Levi,Susan M. Sunkin,Linda Madisen,Tanya L. Daigle,Loren L. Looger,Amy Bernard,John W. Phillips,Ed S. Lein,Michael Hawrylycz,Karel Svoboda,Allan R. Jones,Christof Koch,Hongkui Zeng +46 more
TL;DR: A combined transcriptomic and projectional taxonomy of cortical cell types from functionally distinct regions of the mouse cortex is established and correspondence between excitatory transcriptomic types and their region-specific long-range target specificity is demonstrated.
Journal ArticleDOI
A large-scale standardized physiological survey reveals functional organization of the mouse visual cortex
Saskia E. J. de Vries,Jérôme Lecoq,Michael A. Buice,Peter A. Groblewski,Gabriel Koch Ocker,Michael Oliver,David Feng,Nicholas Cain,Peter Ledochowitsch,Daniel Millman,Kate Roll,Marina Garrett,Tom Keenan,Leonard Kuan,Stefan Mihalas,Shawn R. Olsen,Carol L. Thompson,Wayne Wakeman,Jack Waters,Derric Williams,Chris Barber,Nathan Berbesque,Brandon Blanchard,Nicholas Bowles,Shiella Caldejon,Linzy Casal,Andrew Cho,Sissy Cross,Chinh Dang,Tim A. Dolbeare,Melise Edwards,John Galbraith,Nathalie Gaudreault,Terri L. Gilbert,Fiona Griffin,Perry Hargrave,Robert Howard,Lawrence Huang,Sean Jewell,Nika H. Keller,Ulf Knoblich,Josh D Larkin,Rachael Larsen,Chris Lau,Eric Lee,Felix Lee,Arielle Leon,Lu Li,Fuhui Long,Jennifer Luviano,Kyla Mace,Thuyanh V. Nguyen,Jed Perkins,Miranda Robertson,Sam Seid,Eric Shea-Brown,Eric Shea-Brown,Jianghong Shi,Nathan Sjoquist,Cliff Slaughterbeck,David Sullivan,Ryan Valenza,White C,Ali Williford,Daniela Witten,Jun Zhuang,Hongkui Zeng,Colin Farrell,Lydia Ng,Amy Bernard,John W. Phillips,R. Clay Reid,Christof Koch +72 more
TL;DR: An open, large-scale physiological survey of activity in the awake mouse visual cortex: the Allen Brain Observatory Visual Coding dataset is reported, revealing response specializations within the mouseVisual cortex.
Journal ArticleDOI
Aberrant Cortical Activity in Multiple GCaMP6-Expressing Transgenic Mouse Lines.
Nicholas A. Steinmetz,Nicholas A. Steinmetz,Christina Buetfering,Jérôme Lecoq,Christian R. Lee,Andrew J. Peters,Elina A. K. Jacobs,Philip Coen,Douglas R. Ollerenshaw,Matthew T. Valley,Saskia E. J. de Vries,Marina Garrett,Jun Zhuang,Peter A. Groblewski,Sahar Manavi,Jesse Miles,Casey White,Eric Lee,Fiona Griffin,Joshua D. Larkin,Kate Roll,Sissy Cross,Thuyanh V. Nguyen,Rachael Larsen,Julie Pendergraft,Tanya L. Daigle,Bosiljka Tasic,Carol L. Thompson,Jack Waters,Shawn R. Olsen,David J. Margolis,Hongkui Zeng,Michael Häusser,Matteo Carandini,Kenneth D. Harris +34 more
TL;DR: Aberrant electrical activity, similar to interictal spikes, and accompanying fluorescence events in some genotypes of transgenic mice expressing GCaMP6 genetically encoded calcium sensors are reported, observed particularly in mice with Emx1-Cre and Ai93 transgenes across multiple laboratories.