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Shaila Musharoff
Researcher at Stanford University
Publications - 13
Citations - 766
Shaila Musharoff is an academic researcher from Stanford University. The author has contributed to research in topics: Population & Population genetics. The author has an hindex of 7, co-authored 12 publications receiving 587 citations. Previous affiliations of Shaila Musharoff include University of California, San Francisco & Cornell University.
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Journal ArticleDOI
Distance from sub-Saharan Africa predicts mutational load in diverse human genomes.
Brenna M. Henn,Laura R. Botigué,Stephan Peischl,Isabelle Dupanloup,Mikhail Lipatov,Brian K. Maples,Alicia R. Martin,Shaila Musharoff,Howard M. Cann,Michael Snyder,Laurent Excoffier,Jeffrey M. Kidd,Carlos Bustamante +12 more
TL;DR: It is concluded that many predicted deleterious mutations have evolved as if they were neutral during the expansion out of Africa, but that OOA populations are likely to have a higher mutation load due to increased allele frequencies of nearly neutral variants that are recessive or partially recessive.
Journal ArticleDOI
A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome
Rasika A. Mathias,Margaret A. Taub,Christopher R. Gignoux,Wenqing Fu,Shaila Musharoff,Timothy D. O’Connor,Candelaria Vergara,Dara G. Torgerson,Maria Pino-Yanes,Suyash Shringarpure,Lili Huang,Nicholas Rafaels,Meher Preethi Boorgula,Henry Richard Johnston,Victor E. Ortega,Albert M. Levin,Wei Song,Raul Torres,Badri Padhukasahasram,Celeste Eng,Delmy Aracely Mejia-Mejia,Trevor S. Ferguson,Zhaohui S. Qin,Alan F. Scott,Maria Yazdanbakhsh,James G. Wilson,Javier Marrugo,Leslie A. Lange,Rajesh Kumar,Rajesh Kumar,Pedro C. Avila,L. Keoki Williams,Harold Watson,Lorraine B. Ware,Christopher O. Olopade,Olufunmilayo I. Olopade,Ricardo Riccio Oliveira,Carole Ober,Dan L. Nicolae,Deborah A. Meyers,Alvaro Mayorga,Jennifer Knight-Madden,Tina V. Hartert,Nadia N. Hansel,Marilyn G. Foreman,Jean G. Ford,Jean G. Ford,Mezbah U. Faruque,Georgia M. Dunston,Luis Caraballo,Esteban G. Burchard,Eugene R. Bleecker,Maria Ilma Araujo,Edwin Francisco Herrera-Paz,Kimberly Gietzen,Wendy E. Grus,Michael J. Bamshad,Carlos Bustamante,Eimear E. Kenny,Eimear E. Kenny,Ryan D. Hernandez,Ryan D. Hernandez,Terri H. Beaty,Ingo Ruczinski,Joshua M. Akey,Kathleen C. Barnes +65 more
TL;DR: Genetic variation from deeply sequenced genomes of 642 individuals from North and South American, Caribbean and West African populations is presented, substantially increasing the lexicon of human genomic variation and suggesting much variation remains to be discovered in African-admixed populations in the Americas.
Journal ArticleDOI
Population Genetic Structure of the People of Qatar
Haley Hunter-Zinck,Shaila Musharoff,Jacqueline Salit,Khalid Al-Ali,Lotfi Chouchane,Abeer Gohar,Rebecca Matthews,Marcus W. Butler,Jennifer Fuller,Neil R. Hackett,Ronald G. Crystal,Andrew G. Clark +11 more
TL;DR: The data strongly support the notion that the Q Qatar population could provide a valuable resource for the mapping of genes associated with complex disorders and that tests of pairwise interactions are particularly empowered by populations with elevated LD like the Qatari.
Journal ArticleDOI
Population Genetic Inference from Personal Genome Data: Impact of Ancestry and Admixture on Human Genomic Variation
Jeffrey M. Kidd,Simon Gravel,Jake K. Byrnes,Andrés Moreno-Estrada,Shaila Musharoff,Katarzyna Bryc,Jeremiah D. Degenhardt,Abra Brisbin,Vrunda Sheth,Rong Chen,Stephen F. McLaughlin,Heather E. Peckham,Larsson Omberg,Christina A. Bormann Chung,Sarah Stanley,Kevin A. Pearlstein,Elizabeth Levandowsky,Suehelay Acevedo-Acevedo,Adam Auton,Alon Keinan,Victor Acuña-Alonzo,Rodrigo Barquera-Lozano,Samuel Canizales-Quinteros,Celeste Eng,Esteban G. Burchard,Archie Russell,Andrew R. Reynolds,Andrew G. Clark,Martin G. Reese,Stephen E. Lincoln,Atul J. Butte,Francisco M. De La Vega,Francisco M. De La Vega,Carlos Bustamante +33 more
TL;DR: A systematic analysis of 50 human genomes from 11 diverse global populations sequenced at high coverage identifies subtle variations across populations in the proportion of neutral versus deleterious variation and finds that genome-wide statistics vary in admixed populations even once ancestry proportions have been factored in.
Journal ArticleDOI
Impact of admixture and ancestry on eQTL analysis and GWAS colocalization in GTEx.
Michael J. Gloudemans,Margaret L. Antonio,Nathan S. Abell,Brunilda Balliu,YoSon Park,Alicia R. Martin,Shaila Musharoff,Abhiram Rao,François Aguet,Alvaro N. Barbeira,Rodrigo Bonazzola,Farhad Hormozdiari,Farhad Hormozdiari,Kristin G. Ardlie,Christopher D. Brown,Hae Kyung Im,Tuuli Lappalainen,Xiaoquan Wen,Stephen B. Montgomery +18 more
TL;DR: A local ancestry map for admixed individuals in the GTEx v8 release is provided and the impact of ancestry and admixture on gene expression, eQTLs, and GWAS colocalization is described.