M
Michael A. Kiebler
Researcher at Ludwig Maximilian University of Munich
Publications - 91
Citations - 8488
Michael A. Kiebler is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: RNA & RNA-binding protein. The author has an hindex of 39, co-authored 84 publications receiving 7888 citations. Previous affiliations of Michael A. Kiebler include Medical University of Vienna & Howard Hughes Medical Institute.
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Journal ArticleDOI
A brain-specific microRNA regulates dendritic spine development
Gerhard Schratt,Fabian Tuebing,Elizabeth A. Nigh,Elizabeth A. Nigh,Christina G. Kane,Christina G. Kane,Mary E. Sabatini,Michael A. Kiebler,Michael E. Greenberg,Michael E. Greenberg +9 more
TL;DR: It is shown that a brain-specific microRNA, miR-134>, is localized to the synapto-dendritic compartment of rat hippocampal neurons and negatively regulates the size of dendritic spines—postsynaptic sites of excitatory synaptic transmission.
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Neuronal RNA granules: movers and makers.
TL;DR: Evidence will be discussed that RNA transport and local translation in neurons may be more intimately linked than originally thought and neuronal RNA granules, originally defined as intermediates involved in mRNA transport, are much more diverse in their composition and functions than previously anticipated.
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Long-Term Potentiation Is Reduced in Mice That Are Doubly Mutant in Endothelial and Neuronal Nitric Oxide Synthase
Hyeon Son,Robert D. Hawkins,Kelsey C. Martin,Michael A. Kiebler,Paul L. Huang,Mark C. Fishman,Eric R. Kandel +6 more
TL;DR: The results provide the first genetic evidence that NOS is involved in LTP in stratum radiatum and suggest that the neuronal and endothelial forms can compensate for each other in mice with a single mutation.
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Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons
Ottavio Arancio,Michael A. Kiebler,C. Justin Lee,Varda Lev-Ram,Roger Y. Tsien,Eric R. Kandel,Eric R. Kandel,Robert D. Hawkins +7 more
TL;DR: Results indicate that NO is produced in the postsynaptic neuron, travels through the extracellular space, and acts directly in the presynaptic neuron to produce long-term potentiation, supporting the hypothesis that NO acts as a retrograde messenger during LTP.
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Microtubule-dependent recruitment of Staufen-green fluorescent protein into large RNA-containing granules and subsequent dendritic transport in living hippocampal neurons.
Martin Köhrmann,Ming Luo,Christoph Kaether,Luc DesGroseillers,Carlos G. Dotti,Michael A. Kiebler +5 more
TL;DR: A novel, nonvesicular, microtubule-dependent transport pathway involving RNA-containing granules with Staufen as a core component is characterized and the first demonstration in living neurons of movement of an essential protein constituent of the mRNA transport machinery is demonstrated.