C
Christina Rathke
Researcher at University of Marburg
Publications - 26
Citations - 1243
Christina Rathke is an academic researcher from University of Marburg. The author has contributed to research in topics: Chromatin & Histone. The author has an hindex of 14, co-authored 26 publications receiving 1037 citations.
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Journal ArticleDOI
Chromatin dynamics during spermiogenesis.
TL;DR: This review highlights the current knowledge on post-meiotic chromatin reorganization and reveals for the first time intriguing parallels in this process in Drosophila and mammals and illustrates the possible mechanisms that lead from a histone-based chromatin to a mainly protamine-based structure during spermatid differentiation.
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Transition from a nucleosome-based to a protamine-based chromatin configuration during spermiogenesis in Drosophila.
Christina Rathke,Willy M. Baarends,Sunil Jayaramaiah-Raja,Marek Bartkuhn,Rainer Renkawitz,Renate Renkawitz-Pohl +5 more
TL;DR: This work focuses on post-meiotic stages and shows that also after meiosis, histone H3 shows a high overall methylation of K9 and K27 and hypothesise that these modifications ensure maintenance of transcriptional silencing in the haploid genome.
Journal ArticleDOI
Active promoters and insulators are marked by the centrosomal protein 190.
Marek Bartkuhn,Tobias Straub,Martin Herold,Mareike Herrmann,Christina Rathke,Harald Saumweber,Gregor D. Gilfillan,Peter B. Becker,Rainer Renkawitz +8 more
TL;DR: For the compact Drosophila genome, several factors mediating insulator function, such as su(Hw) and dCTCF, have been identified and it is shown that both these insulator‐binding factors are functionally dependent on the same cofactor, CP190.
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Distinct functions of Mst77F and protamines in nuclear shaping and chromatin condensation during Drosophila spermiogenesis
Christina Rathke,Bridlin Barckmann,Silja Burkhard,Sunil Jayaramaiah-Raja,John Roote,Renate Renkawitz-Pohl +5 more
TL;DR: Data support the long-standing hypothesis that the switch from a histone- to protamine-based chromatin protects the paternal genome from mutagens.
Journal ArticleDOI
H3K79 methylation directly precedes the histone‐to‐protamine transition in mammalian spermatids and is sensitive to bacterial infections
Christine Dottermusch-Heidel,E. S. Klaus,Nicola Helena Gonzalez,Sudhanshu Bhushan,Andreas Meinhardt,Martin Bergmann,Renate Renkawitz-Pohl,Christina Rathke,Klaus Steger +8 more
TL;DR: The results indicated that H3K79 methylation is a histone modification conserved in Drosophila, mouse, rat and human spermatids and may be a prerequisite for proper chromatin reorganization.