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Stephan Awe
Researcher at University of Marburg
Publications - 9
Citations - 916
Stephan Awe is an academic researcher from University of Marburg. The author has contributed to research in topics: Chromatin & Gene. The author has an hindex of 8, co-authored 9 publications receiving 744 citations.
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Journal ArticleDOI
Chromatin dynamics during spermiogenesis.
TL;DR: This review highlights the current knowledge on post-meiotic chromatin reorganization and reveals for the first time intriguing parallels in this process in Drosophila and mammals and illustrates the possible mechanisms that lead from a histone-based chromatin to a mainly protamine-based structure during spermatid differentiation.
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Transcriptome-wide distribution and function of RNA hydroxymethylcytosine
Benjamin Delatte,Fei Wang,Long Vo Ngoc,Evelyne Collignon,Elise Bonvin,Rachel Deplus,Emilie Calonne,Bouchra Hassabi,Pascale Putmans,Stephan Awe,Collin Wetzel,Judith Kreher,Romuald Soin,Catherine Creppe,Patrick A. Limbach,Cyril Gueydan,Véronique Kruys,Alexander Brehm,Svetlana Minakhina,Matthieu Defrance,Ruth Steward,François Fuks +21 more
TL;DR: It is found that RNA hydroxymethylation can favor mRNA translation and is found to be most abundant in the Drosophila brain, and Tet-deficient fruitflies suffer impaired brain development, accompanied by decreased RNA hydroxyethylation.
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Histone H4 acetylation is essential to proceed from a histone- to a protamine-based chromatin structure in spermatid nuclei of Drosophila melanogaster.
TL;DR: H4 hyperacetylation is an essential feature but not the sole inducer of the histone to protamine switch during spermiogenesis, and inactivation of histone acetyltransferases by anacardic acid blocks further differentiation and thus prevents the degradation of histones and the switch to a protamine-based chromatin.
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Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner.
Kristina Kovač,Anja Sauer,Igor Mačinković,Stephan Awe,Florian Finkernagel,Helen Hoffmeister,Andreas Fuchs,Rolf Müller,Christina Rathke,Gernot Längst,Alexander Brehm +10 more
TL;DR: The nucleosome remodelling properties of cancer-associated mutants of the Drosophila Chd4 homolog dMi-2 are characterized and the chromodomains and a novel regulatory region are defined as essential for nucleosomes remodelling.
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Blocking promiscuous activation at cryptic promoters directs cell type-specific gene expression.
Jongmin Kim,Chenggang Lu,Shrividhya Srinivasan,Stephan Awe,Alexander Brehm,Margaret T. Fuller +5 more
TL;DR: The results suggest that as new regions of the genome become open for transcription during terminal differentiation, blocking the action of a promiscuous activator on cryptic promoters is a critical mechanism for specifying precise gene activation.