C
Christina Reith
Researcher at Clinical Trial Service Unit
Publications - 46
Citations - 10480
Christina Reith is an academic researcher from Clinical Trial Service Unit. The author has contributed to research in topics: Kidney disease & Statin. The author has an hindex of 20, co-authored 36 publications receiving 8749 citations. Previous affiliations of Christina Reith include University of Oxford.
Papers
More filters
Journal ArticleDOI
Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials.
Colin Baigent,L Blackwell,Jonathan Emberson,Lisa Holland,Christina Reith,Neeraj Bhala,Richard Peto,Elizabeth H Barnes,Anthony C Keech,John Simes,Rory Collins +10 more
TL;DR: Further reductions in LDL cholesterol safely produce definite further reductions in the incidence of heart attack, of revascularisation, and of ischaemic stroke, with each 1·0 mmol/L reduction reducing the annual rate of these major vascular events by just over a fifth.
Journal ArticleDOI
The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial
Colin Baigent,Martin J Landray,Christina Reith,Jonathan Emberson,David C. Wheeler,Charles R.V. Tomson,Christoph Wanner,Vera Krane,Alan Cass,Jonathan C. Craig,Bruce Neal,Lixin Jiang,Lai Seong Hooi,Adeera Levin,Lawrence Y. Agodoa,Mike Gaziano,Bertram L. Kasiske,Robert J. Walker,Ziad A. Massy,Bo Feldt-Rasmussen,Udom Krairittichai,Vuddidhej Ophascharoensuk,Bengt Fellström,Hallvard Holdaas,Vladimir Tesar,Andrzej Wiecek,Diederick E. Grobbee,Dick de Zeeuw,Carola Grönhagen-Riska,Tanaji Dasgupta,David Lewis,William G. Herrington,Marion Mafham,William Majoni,K Wallendszus,Richard H. Grimm,Terje R. Pedersen,Jonathan A. Tobert,Jane Armitage,Alex Baxter,Christopher Bray,Yiping Chen,Zhengming Chen,Michael Hill,Carol Knott,Sarah Parish,David Simpson,Peter Sleight,Alan Young,Rory Collins +49 more
TL;DR: Reduction of LDL cholesterol with simvastatin 20 mg plus ezetimibe 10 mg daily safely reduced the incidence of major atherosclerotic events in a wide range of patients with advanced chronic kidney disease.
Journal ArticleDOI
Interpretation of the evidence for the efficacy and safety of statin therapy.
Rory Collins,Christina Reith,Jonathan Emberson,Jane Armitage,Colin Baigent,Lisa Blackwell,Roger S. Blumenthal,John Danesh,George Davey Smith,David L. DeMets,Stephen J. W. Evans,Malcolm Law,Stephen MacMahon,Seth S. Martin,Bruce Neal,Neil R Poulter,David Preiss,Paul M. Ridker,Ian Roberts,Anthony Rodgers,Peter Sandercock,Kenneth F. Schulz,Peter S. Sever,John Simes,Liam Smeeth,Nicholas J. Wald,Salim Yusuf,Richard Peto +27 more
TL;DR: The large-scale evidence from randomised trials indicates that it is unlikely that large absolute excesses in other serious adverse events still await discovery, and any further findings that emerge about the effects of statin therapy would not be expected to alter materially the balance of benefits and harms.
Journal ArticleDOI
Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials
Jane Armitage,Colin Baigent,Elizabeth H Barnes,D. John Betteridge,Lisa Blackwell,Michael A. Blazing,Louise Bowman,Eugene Braunwald,Robert P Byington,Christopher P. Cannon,Michael Clearfield,Helen M. Colhoun,Rory Collins,Björn Dahlöf,Kelly Davies,Barry R. Davis,James A. de Lemos,John R. Downs,Paul N. Durrington,Jonathan Emberson,Bengt Fellström,Marcus Flather,Ian Ford,Maria Grazia Franzosi,Jordan Fulcher,John H. Fuller,Curt D. Furberg,David L. Gordon,Shinya Goto,Antonio M. Gotto,Heather Halls,Charlie H.S. Harper,C. Morton Hawkins,William G. Herrington,Graham A. Hitman,Hallvard Holdaas,Lisa Holland,Alan G. Jardine,J. Wouter Jukema,John J.P. Kastelein,Sharon Kean,Anthony C Keech,Adrienne Kirby,John Kjekshus,Genell L. Knatterud,Robert H. Knopp,Wolfgang Koenig,Michael J. Koren,Vera Krane,Martin J Landray,John C. LaRosa,Eva Lonn,Peter W. Macfarlane,Stephen MacMahon,Aldo P. Maggioni,Roberto Marchioli,Ian C. Marschner,Borislava Mihaylova,Lemuel A. Moyé,Sabina A. Murphy,Haruo Nakamura,Andrew Neil,Connie B. Newman,Rachel O'Connell,Chris J. Packard,Sarah Parish,Terje R. Pedersen,Richard Peto,Marc A. Pfeffer,Neil Poulter,David Preiss,Christina Reith,Paul M. Ridker,Michele Robertson,Frank M. Sacks,Naveed Sattar,Roland E. Schmieder,Patrick W. Serruys,Peter S. Sever,John Shaw,Charles L. Shear,John Simes,Peter Sleight,Enti Spata,Luigi Tavazzi,Jonathan A. Tobert,Gianni Tognoni,Andrew Tonkin,Stella Trompet,John Varigos,Christoph Wanner,Hans Wedel,Harvey D. White,John Wikstrand,Lars Wilhelmsen,Kate Wilson,R. Young,Salim Yusuf,Faiez Zannad +98 more
TL;DR: A meta-analysis of data from all large statin trials to compare the effects of statin therapy at different ages observed a significant reduction in major vascular events in all age groups.
Journal ArticleDOI
Lack of effect of lowering LDL cholesterol on cancer: Meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy
Jonathan Emberson,Patricia M. Kearney,Lisa Blackwell,Connie B. Newman,Christina Reith,Neeraj Bhala,Lisa Holland,Richard Peto,Anthony C Keech,Rory Collins,John Simes,Colin Baigent +11 more
TL;DR: In this article, a detailed assessment of any effects on cancer of lowering LDL cholesterol (LDL-C) with a statin using individual patient records from 175,000 patients in 27 large-scale statin trials was provided.