C
Christina Wong
Researcher at Harvard University
Publications - 7
Citations - 781
Christina Wong is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Drosophila Protein. The author has an hindex of 3, co-authored 7 publications receiving 664 citations.
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Journal ArticleDOI
A Protein Complex Network of Drosophila melanogaster
K. G. Guruharsha,Jean François Rual,Bo Zhai,Julian Mintseris,Pujita Vaidya,Namita Vaidya,Chapman N. Beekman,Christina Wong,David Y. Rhee,Odise Cenaj,Emily McKillip,Saumini Shah,Mark Stapleton,Kenneth H. Wan,Charles Yu,Bayan Parsa,Joseph W. Carlson,Xiao Chen,Bhaveen Kapadia,K. VijayRaghavan,Steven P. Gygi,Susan E. Celniker,Robert A. Obar,Spyros Artavanis-Tsakonas +23 more
TL;DR: The Drosophila protein interaction map (DPiM) represents the largest metazoan protein complex map and provides a valuable resource for analysis of protein complex evolution.
Journal ArticleDOI
Transcription Factor Networks in Drosophila melanogaster
David Y. Rhee,Dong-Yeon Cho,Bo Zhai,Matthew Slattery,Lijia Ma,Julian Mintseris,Christina Wong,Kevin P. White,Susan E. Celniker,Teresa M. Przytycka,Steven P. Gygi,Robert A. Obar,Spyros Artavanis-Tsakonas,Spyros Artavanis-Tsakonas +13 more
TL;DR: This work defines protein-protein interactions using a coaffinity purification/mass spectrometry method and studies 459 Drosophila melanogaster transcription-related factors to define an integrated network that connects combinatorial TF protein interactions to the transcriptional regulatory network of the cell.
Journal ArticleDOI
Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
Zohreh Amoozgar,Jonas Kloepper,Jun Ren,Rong En Tay,Samuel W. Kazer,Evgeny Kiner,Shanmugarajan Krishnan,Jessica M. Posada,Mitrajit Ghosh,Emilie Mamessier,Christina Wong,Gino B. Ferraro,Ana Batista,Nancy Wang,Mark Badeaux,Sylvie Roberge,Lei Xu,Peigen Huang,Alex K. Shalek,Dai Fukumura,Hye-Jung Kim,Rakesh K. Jain +21 more
TL;DR: In this paper, the authors show that regulatory T (Treg) cells play a key role in GBM resistance to ICBs in experimental gliomas, by targeting glucocorticoid-induced TNFR-related receptor (GITR) in Treg cells using an agonistic antibody.
Proceedings ArticleDOI
Abstract 4846: MM-401, a novel anti-TNFR2 antibody that induces T cell co-stimulation, robust anti-tumor activity and immune memory
Jennifer Richards,Christina Wong,Alexander Koshkaryev,Ross B. Fulton,Adam Camblin,James F. Sampson,Lia Luus,James Suchy,Stephanie Grabow,Vinodh B. Kurella,Sandeep Kumar,James Lulo,James Qiu,Yang Jiao,Lihui Xu,Violette Paragas,Maja Razlog,Marco Muda,Eric M. Tam,Andreas Raue,Daryl C. Drummond +20 more
TL;DR: A novel monoclonal anti-TNFR2 antibody that provides T cell co-stimulation and yields robust anti-tumor activity in in vitro and in vivo models and is being developed as a potential novel treatment option for cancer patients.
Proceedings ArticleDOI
Abstract 5546: A murine reactive version of TAK-573 (anti-CD38 attenuated IFNα fusion protein) shows immunomodulatory and antitumor activity, alone and in combination with standard-of-care agents, in IFNa-insensitive, immunocompetent murine multiple myeloma tumor models
Tomoya Hara,Christina Wong,Jie Yu,Sabrina Collins,Haiqing Wang,Hiroshi Sugimoto,Hong Zhang,Pia Bjorck,Michael Curley +8 more