C
Christina Y. Chan
Researcher at Merck & Co.
Publications - 15
Citations - 2740
Christina Y. Chan is an academic researcher from Merck & Co.. The author has contributed to research in topics: Varicella vaccine & Vaccination. The author has an hindex of 14, co-authored 15 publications receiving 2604 citations.
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Journal ArticleDOI
A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults.
Michael N. Oxman,Michael N. Oxman,Myron J. Levin,Gary R. Johnson,Kenneth E. Schmader,Sharon E. Straus,Lawrence D. Gelb,Robert D. Arbeit,Michael S. Simberkoff,Anne A. Gershon,Larry E. Davis,Adriana Weinberg,Kathy D. Boardman,Heather M. Williams,J. Hongyuan Zhang,Peter Peduzzi,C. E. Beisel,Vicki A. Morrison,John C. Guatelli,P. A. Brooks,C. A. Kauffman,Constance T. Pachucki,Kathleen M. Neuzil,Robert F. Betts,Peter F. Wright,Marie R. Griffin,P. Brunell,N. E. Soto,Adriana Marques,Susan Keay,R. P. Goodman,D. J. Cotton,John W. Gnann,J. Loutit,Mark Holodniy,Wendy A. Keitel,George E. Crawford,S. S. Yeh,Z. Lobo,John F. Toney,Richard N. Greenberg,Paul M. Keller,Ruth Harbecke,Anthony R. Hayward,Michael R. Irwin,Tassos C. Kyriakides,Christina Y. Chan,Ivan S. F. Chan,William Wang,Paula W. Annunziato,Jeffrey L. Silber +50 more
TL;DR: The zoster vaccine markedly reduced morbidity from herpes zoster and postherpetic neuralgia among older adults and significantly reduced the burden of illness due to herpesZoster.
Journal ArticleDOI
Inverse relationship between six week postvaccination varicella antibody response to vaccine and likelihood of long term breakthrough infection.
Shu Li,Ivan S. F. Chan,Holly Matthews,Joseph F. Heyse,Christina Y. Chan,Barbara J. Kuter,Karen M. Kaplan,S. J. Vessey,Jerald C. Sadoff +8 more
TL;DR: A 6-week postvaccination antibody titer of ≥5 gpELISA units was identified as an approximate correlate of protection and an accelerated failure time model was established based on log normal hazard that predicted varicella breakthrough rates based on the distribution of 6- week post vaccination variceella antibody titers.
Journal ArticleDOI
Bowel colonization with resistant gram-negative bacilli after antimicrobial therapy of intra-abdominal infections: observations from two randomized comparative clinical trials of ertapenem therapy
Mark J. DiNubile,Ian R. Friedland,Christina Y. Chan,Mary Motyl,Hilde Giezek,Malathi Shivaprakash,Robert A. Weinstein,John P. Quinn +7 more
TL;DR: The frequency of bowel colonization with resistant Enterobacteriaceae substantially increased in patients treated with either piperacillin-tazobactam or ceftriaxone/metronidazole, but not in patients treating with ertapenem, and the prevalence of ESBL-producers increased significantly during therapy in OASIS II.
Journal ArticleDOI
Childhood vaccination against varicella: persistence of antibody, duration of protection, and vaccine efficacy.
S J Rupert Vessey,Christina Y. Chan,Barbara J. Kuter,Karen M. Kaplan,Marilyn Waters,David P. Kutzler,Patricia A. Carfagno,Jerald C. Sadoff,Joseph F. Heyse,Holly Matthews,Shu Li,Ivan S. F. Chan +11 more
TL;DR: The live attenuated varicella vaccine is highly effective in inducing persistent immunity and long-term protection against breakthroughvaricella infection.
Journal ArticleDOI
Varicella vaccination in children with chronic renal failure. A report of the Southwest Pediatric Nephrology Study Group.
Susan L. Furth,Ronald J. Hogg,Joyce Tarver,Lawrence H. Moulton,Christina Y. Chan,Barbara A. Fivush +5 more
TL;DR: In this study, varicella vaccination with a two-dose regimen ofvaricella vaccine was generally well tolerated and highly immunogenic in children with chronic kidney disease.