H
Heather M. Williams
Researcher at United States Department of Veterans Affairs
Publications - 13
Citations - 3546
Heather M. Williams is an academic researcher from United States Department of Veterans Affairs. The author has contributed to research in topics: Zoster vaccine & Shingles. The author has an hindex of 12, co-authored 13 publications receiving 3317 citations. Previous affiliations of Heather M. Williams include National Institutes of Health & University of California, San Diego.
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Journal ArticleDOI
A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults.
Michael N. Oxman,Michael N. Oxman,Myron J. Levin,Gary R. Johnson,Kenneth E. Schmader,Sharon E. Straus,Lawrence D. Gelb,Robert D. Arbeit,Michael S. Simberkoff,Anne A. Gershon,Larry E. Davis,Adriana Weinberg,Kathy D. Boardman,Heather M. Williams,J. Hongyuan Zhang,Peter Peduzzi,C. E. Beisel,Vicki A. Morrison,John C. Guatelli,P. A. Brooks,C. A. Kauffman,Constance T. Pachucki,Kathleen M. Neuzil,Robert F. Betts,Peter F. Wright,Marie R. Griffin,P. Brunell,N. E. Soto,Adriana Marques,Susan Keay,R. P. Goodman,D. J. Cotton,John W. Gnann,J. Loutit,Mark Holodniy,Wendy A. Keitel,George E. Crawford,S. S. Yeh,Z. Lobo,John F. Toney,Richard N. Greenberg,Paul M. Keller,Ruth Harbecke,Anthony R. Hayward,Michael R. Irwin,Tassos C. Kyriakides,Christina Y. Chan,Ivan S. F. Chan,William Wang,Paula W. Annunziato,Jeffrey L. Silber +50 more
TL;DR: The zoster vaccine markedly reduced morbidity from herpes zoster and postherpetic neuralgia among older adults and significantly reduced the burden of illness due to herpesZoster.
Journal ArticleDOI
Varicella-Zoster Virus–Specific Immune Responses in Elderly Recipients of a Herpes Zoster Vaccine
Myron J. Levin,Michael N. Oxman,Jane H. Zhang,Gary R. Johnson,Harold A. Stanley,A. R Hayward,Michael J. Caulfield,Michael R. Irwin,Jeffrey G. Smith,Jim Clair,Ivan S. F. Chan,Heather M. Williams,Ruth Harbecke,Rocio D. Marchese,Sharon E. Straus,Anne A. Gershon,Adriana Weinberg +16 more
TL;DR: The hypothesis that boosting VZV-CMI protects older adults against herpes zoster and postherpetic neuralgia is supported, as it paralleled the clinical effects of the vaccine observed during the efficacy trial.
Journal ArticleDOI
Development of a measure of the burden of pain due to herpes zoster and postherpetic neuralgia for prevention trials: adaptation of the brief pain inventory.
Paul Coplan,Paul Coplan,Kenneth E. Schmader,Alexander Nikas,Ivan S. F. Chan,Peter W. Choo,Myron J. Levin,Gary R. Johnson,Mark S. Bauer,Heather M. Williams,Karen M. Kaplan,Harry A. Guess,Michael N. Oxman +12 more
TL;DR: The Zoster Brief Pain Inventory (ZBPI) as mentioned in this paper is an HZ-specific questionnaire to quantify HZ pain and discomfort, an operational definition of postherpetic neuralgia (PHN), and a severity-duration measure of the burden of illness caused by HZ.
Journal ArticleDOI
Varicella-Zoster Virus–Specific Immune Responses to Herpes Zoster in Elderly Participants in a Trial of a Clinically Effective Zoster Vaccine
Adriana Weinberg,Jane H. Zhang,Michael N. Oxman,Gary R. Johnson,Anthony R. Hayward,Michael J. Caulfield,Michael R. Irwin,James H. Clair,Jeffrey G. Smith,Harold A. Stanley,Rocio D. Marchese,Ruth Harbecke,Heather M. Williams,Ivan S. F. Chan,Robert D. Arbeit,Anne A. Gershon,Florian Schödel,Vicki A. Morrison,Carol A. Kauffman,Steve E. Straus,Kenneth E. Schmader,Larry E. Davis,Myron J. Levin +22 more
TL;DR: Higher VZV CMI at HZ onset was associated with reduced HZ severity and less postherpetic neuralgia, and higher antibody titers were associated with increased H zoster vaccine severity and occurrence of postherPetic Neuralgia.
Journal ArticleDOI
The impact of acute herpes zoster pain and discomfort on functional status and quality of life in older adults.
Kenneth E. Schmader,Richard Sloane,Carl F. Pieper,Paul Coplan,Alexander Nikas,Patricia Saddier,Ivan S. F. Chan,Peter W. Choo,Myron J. Levin,Gary R. Johnson,Heather M. Williams,Michael N. Oxman +11 more
TL;DR: HZ pain interfered with all ADLs but interference was greatest for enjoyment of life, sleep, general activity, leisure activities, getting out of the house, and shopping, and the magnitude of interference increases with increasing pain and discomfort intensity.