C
Christine Lagorce-Pagès
Researcher at Paris Descartes University
Publications - 8
Citations - 5840
Christine Lagorce-Pagès is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Cancer & Colorectal cancer. The author has an hindex of 5, co-authored 8 publications receiving 4992 citations.
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Journal ArticleDOI
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
Jérôme Galon,Anne Costes,Fátima Sánchez-Cabo,Amos Kirilovsky,Bernhard Mlecnik,Christine Lagorce-Pagès,Marie Tosolini,Matthieu Camus,Anne Berger,Philippe Wind,Franck Zinzindohoué,Patrick Bruneval,Paul-Henri Cugnenc,Zlatko Trajanoski,Wolf H. Fridman,Franck Pagès +15 more
TL;DR: In situ analysis of tumor-infiltrating immune cells may be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies.
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Signet-ring cell carcinoma of the stomach: Impact on prognosis and specific therapeutic challenge.
Simon Pernot,Thibault Voron,Géraldine Perkins,Christine Lagorce-Pagès,Anne Berger,Julien Taieb +5 more
TL;DR: In this review, recent data on the epidemiology, oncogenesis, prognosis and specific therapeutic strategies in both early and advanced SRCC of the stomach and in hereditary diffuse gastric cancer are analyzed.
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Epstein-Barr virus nuclear antigen 2 induces interleukin-18 receptor expression in B cells
Franck Pagès,Jérôme Galon,Galina Karaschuk,Diana Dudziak,Mathieu Camus,Vladimir Lazar,Sophie Camilleri-Broët,Christine Lagorce-Pagès,Sophie Lebel-Binay,Gerhard Laux,Wolf H. Fridman,Berthold Henglein +11 more
TL;DR: It is shown that the EBV nuclear antigen EBNA2 induces expression of the 2 chains of the interleukin-18 receptor (IL-18R) in Burkitt lymphoma (BL) cell lines and in nontransformed B cells, and that the IL- 18 receptor expressed in EBV-infected BL cells has signaling capacity, because IL-18 significantly modified gene expression.
Journal ArticleDOI
The consensus immunoscore: toward a new classification of colorectal cancer.
Anastasia Lanzi,Anastasia Lanzi,Franck Pagès,Christine Lagorce-Pagès,Jérôme Galon,Jérôme Galon +5 more
TL;DR: The international validation of the prognostic value of the consensus Immunoscore for time to recurrence, disease-free survival and overall survival in colon cancer together with its predictive value of response to chemotherapy provides valuable information for patient care management.
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Evaluation of the prognostic impact of pathologic response to preoperative chemotherapy using Mandard’s Tumor Regression Grade (TRG) in gastric adenocarcinoma
Simon Derieux,Magali Svrcek,Sarah Manela,Christine Lagorce-Pagès,Anne Berger,Thierry André,Julien Taieb,François Paye,Thibault Voron +8 more
TL;DR: TRG after preoperative chemotherapy is an important prognostic factor in patients resected for a gastric adenocarcinoma and further studies should be performed to evaluate if adjuvant therapy should be adapted to pathological response.