Showing papers in "Seminars in Immunology in 2018"

TL;DR: The mechanisms associated with the performance of those adjuvanted vaccines in animal models and in humans are reviewed, paving the way for the development of novel vaccines at the extremes of age and against infections with a high toll of morbidity and mortality.

TL;DR: The more that can be understood about the interplay between SCs and the immune system, the faster new interventions may be developed to delay, prevent, or treat age-related dysfunction and the multiple senescence-associated chronic diseases and disorders.

TL;DR: The impact of age-associated factors such as inflammaging, immunosenescence and immunobiography on immune response to vaccination in the elderly is analyzed, and systems biology approaches are considered as a mean for integrating a multitude of data in order to rationally design vaccination approaches specifically tailored for the elderly.

TL;DR: The ubiquitous nuclear molecule high-mobility group box 1 protein (HMGB1) is a prototypical alarmin activating innate immunity that serves a dualAlarmins are preformed, endogenous molecules that can be promptly released to signal cell or tissue stress or damage.

TL;DR: An overview on the definition and characterization of PMN-MDSC and neutrophils, their pathological significance in a variety of diseases, and their interaction with other stromal components is provided.

TL;DR: Although MSCs have a potential to exert anti-tumor activities, they largely provide service to the tumor using the multidirectional communication system established by exosomes in the TME.

TL;DR: The concept of inflammaging is described, being a chronic, systemic, low grade and therefore for a long time subclinical, inflammatory process, and how it is integrated in the context of ARD.

TL;DR: An overview of the epidemiological evidence of non-specific effects of vaccines and the latest insights regarding the biological mechanisms behind this phenomenon is presented, and future research priorities and potential implications are discussed.

TL;DR: The glycan profile of antibodies has been unravelled in great detail in inflammatory (auto)immune diseases but received only limited attention in the area of infectious diseases and vaccination, an area with a lot of interesting opportunities.

TL;DR: This work discusses the emerging concept that a key innate immune pathway, the NLRP3 inflammasome, is centrally involved in the recognition of triggers that appear during physiological aging and during metabolic stress and highlights potential strategies by which the detrimental inflammatory responses could be pharmacologically addressed.

TL;DR: It is argued that uncontrolled smoldering inflammation drives carcinogenesis in aging and acts as a common denominator linking aging and cancer.

TL;DR: This work focuses here on autosomal and X-linked recessive traits underlying complete deficiencies of the encoded protein, and observations are of potential interest to present-day biologists testing immunological hypotheses experimentally and physicians managing patients with immunological or infectious conditions.

TL;DR: The molecular properties of the tumor endothelial barrier and endothelial anergy are discussed and the main immunosuppressive mechanisms triggered by the tumors endothelium are discussed to discuss the current anti-angiogenic therapeutic landscape.

TL;DR: How IECs, intestinal bacteria and epithelial cell expressed complement components interact in the course of IBD still remains to be mostly elucidated to define potential unique patterns contributing to the distinct subtypes of intestinal inflammation observed in CD and UC.

TL;DR: Compelling evidence suggests that this C5a/C5aR1-LTB4/BLT1 axis driving granulocyte recruitment in arthritis may represent a more generalizable biological principle critically regulating effector cell recruitment in other IgG autoantibody-induced diseases, such as in pemphigoid diseases.

TL;DR: The literature and in combination with the own data, it is suggested that the Appendix might be redundant in its immunological function but unique as a reservoir of microbiota.

TL;DR: The present review summarises the current view on the role of the complement cascade on bone, both under homeostatic physiological conditions and under inflammatory and infectious conditions, which strongly affect the bone and skeletal health.

TL;DR: Basophils, eosinophils and mast cells are able to interact with immune and non-immune components of the tissue microenvironment, contributing to the regulation of tissue homeostasis and immune response while participating to further deregulation of tissues transforming into neoplasia.

TL;DR: Recent observations link complement activation to cellular metabolic processes, intracellular defense reactions and to diverse adaptive immune responses, and the complement components may thus be viewed as intrACEllular alarm molecules involved in the cellular danger response.

TL;DR: An overview of the immunocorrelates of those CAF adjuvants furthest in development with distinct immunogenicity profiles correlating with protection for any given infectious disease is given.

TL;DR: The role of IL-32 and its different isoforms in carcinogenesis, invasion and metastasis, angiogenesis and regulation of the anti-tumor immune response is provided.

TL;DR: The analysis of vaccine-induced immune responses and clinical activity of therapeutic cancer vaccines revealed four levels of evidence for vaccine efficacy, with extrapolation of the results from vaccinated patients with pre-cancers suggest a requirement of broad type 1 T cell reactivity.

TL;DR: The role of complement factors associated with platelet activation in tissue remodeling and the clinical relevance of this platelet-complement crosstalk is addressed and a focus lies on thrombo-inflammatory disorders, other diseases with thrombolic mechanisms or complications, but also autoimmune diseases.

TL;DR: Recent progress in the understanding of immunostimulatory vs. immunoregulatory functions of complement and potential applications of these findings to the design of novel therapies for cancer patients are focused on.

TL;DR: This review is an attempt to provide an overview of the recent efforts in systems analysis of vaccine adjuvants that are currently in clinic.

TL;DR: In this review, proteomic-, transcriptomic and metabolomic research strategies aiming at identification of host biomarker-based correlates of leprosy reactions are discussed, next to external factors associated with occurrence of these episodes.

TL;DR: A systems biology approach, integrating clinical, immunological, transcriptomic and metabolomic data from pre-clinical and clinical vaccine studies, together with data from disease survivors, will be instrumental to identify Ebola vaccine correlates of protection.

TL;DR: To achieve TB eradication, the discovery of Mtb antigens that effectively correlate with the human response to infection, with the curative host response following TB treatment, and with natural as well as vaccine induced protection will be critical.

TL;DR: The cross-talk plays a fundamental role in tissue homeostasis, not only to regulate inflammation, but also to promote tissue regeneration and cancer progression.