Christof J. Majoor

TL;DR: In vitro measurements of CFTR function in patient-derived rectal organoids may be useful for identifying subjects who would benefit from CFTR-correcting treatment, independent of their CFTR mutation.

TL;DR: It is demonstrated that in-vitro drug responses in rectal organoids from individual patients with cystic fibrosis correlate with changes in two in vivo therapeutic endpoints and suggested that biobanked stem cell resources can be used to tailor individual treatments in a cost-effective and patient-friendly manner.

TL;DR: Current knowledge of the impact of the disturbed hemostatic balance in the lungs on asthma severity and manifestations is summarized and new possible targets for asthma treatment are identified.

TL;DR: Assessment of the incidence of venous thromboembolic events in patients with mild-to-moderate and severe asthma as compared with an age- and sex-matched reference population found asthma greatly enhances the risk of pulmonary embolism, particularly if chronic corticosteroids are used.

TL;DR: Initial murine studies led to further explore a potential intracellular antiviral activity by eosinophils, which can also display protective properties like an extracellular antivirus activity.