Christoph Hoffmeister

TL;DR: This article performed RNA-seq of whole blood cell transcriptomes and granulocyte preparations from mild and severe COVID-19 patients and analyzed the data using a combination of conventional and data-driven co-expression analysis.

TL;DR: Comparison of COVID-19 blood transcriptomes with those of a collection of over 2,600 samples derived from 11 different viral infections, inflammatory diseases and independent control samples revealed highly specific transcriptome signatures for CO VID-19, which predicted patient subgroup-specific drug candidates targeting the dysregulated systemic immune response of the host.

TL;DR: In this article , the authors identify a population of liver-type ILC1s with transcriptional, phenotypic, and functional features distinct from those of conventional and liver-resident NK cells as well as from other previously described human IL1 subsets.

TL;DR: It is demonstrated that stimulation of HIV(+) NK cells with MitoTEMPO, mitochondria-targeting antioxidant, significantly improved IFNγ production and identified mitochondrial dysfunction as a mechanism that contributes to impaired NK cell function.

TL;DR: In this paper , the authors observed that HIV infection was associated with increased plasma levels of IFABP, a marker for gut epithelial barrier dysfunction, and LBP (a marker for microbial translocation), suggesting increased microbial translocated to be involved in HIV-associated NK cell dysfunction.