Nikolaos Antonakos

TL;DR: In this paper, the authors found that severe respiratory failure (SRF) in COVID-19 patients is driven by a unique pattern of immune dysfunction, characterized by IL-6-mediated low HLA-DR expression and lymphopenia, associated with sustained cytokine production and hyper-inflammation.

TL;DR: Data show that BCG vaccination is safe and can protect the elderly against infections, and larger studies are needed to assess protection against respiratory infections, including COVID-19.

TL;DR: This article performed RNA-seq of whole blood cell transcriptomes and granulocyte preparations from mild and severe COVID-19 patients and analyzed the data using a combination of conventional and data-driven co-expression analysis.

TL;DR: Comparison of COVID-19 blood transcriptomes with those of a collection of over 2,600 samples derived from 11 different viral infections, inflammatory diseases and independent control samples revealed highly specific transcriptome signatures for CO VID-19, which predicted patient subgroup-specific drug candidates targeting the dysregulated systemic immune response of the host.

TL;DR: The epidemiology of sepsis in Greece differs in the general ward (GW) and in the ICU; MDR Gram-negatives predominated in both periods; de-escalation in the GW is a safe strategy.