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Christoph Weigel
Researcher at Ohio State University
Publications - 16
Citations - 335
Christoph Weigel is an academic researcher from Ohio State University. The author has contributed to research in topics: Epigenetics & DNA methylation. The author has an hindex of 9, co-authored 16 publications receiving 246 citations. Previous affiliations of Christoph Weigel include Epigenomics AG & James Cancer Hospital.
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Journal ArticleDOI
Epigenetics in radiation-induced fibrosis.
TL;DR: The synopsis illustrates the complexity of radiation-induced fibrosis and reveals the need for investigations to further unravel its molecular mechanisms, and points out the important role for epigenetic mechanisms such as DNA methylation, microRNAs and histone modifications in the development of this disease.
Journal ArticleDOI
Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis
Christoph Weigel,Marlon R. Veldwijk,Christopher C. Oakes,Petra Seibold,Alla Slynko,David B. Liesenfeld,Mariona Rabionet,Sabrina Hanke,Frederik Wenz,Elena Sperk,Axel Benner,Christoph Rösli,Roger Sandhoff,Yassen Assenov,Yassen Assenov,Christoph Plass,Carsten Herskind,Jenny Chang-Claude,Peter Schmezer,Odilia Popanda +19 more
TL;DR: DNA methylation profiling of dermal fibroblasts obtained from breast cancer patients prior to irradiation identifies differences associated with fibrosis as well as an epigenetically deregulated kinase involved in radiation response that may serve as a marker and therapeutic target for personalized radiotherapy.
Journal ArticleDOI
TET-mediated hydroxymethylcytosine at the Pparγ locus is required for initiation of adipogenic differentiation.
Yeongran Yoo,Joo Hyun Park,Christoph Weigel,David B. Liesenfeld,Dieter Weichenhan,Christoph Plass,D. G. Seo,Anders Lindroth,Yoon Jung Park +8 more
TL;DR: TET proteins, particularly TET2, were required for adipogenesis by modulating DNA methylation at the P parγ locus, subsequently by inducing Pparγ gene expression.
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Epigenetic reprogramming sensitizes immunologically silent EBV+ lymphomas to virus-directed immunotherapy.
Tanner Dalton,Ekaterina Doubrovina,Dmitry Pankov,Raymond Reynolds,Hanna Scholze,Annamalai Selvakumar,Teresa Vizconde,Bhumesh Savalia,Vadim G. Dyomin,Christoph Weigel,Christopher C. Oakes,Alicia Alonso,Olivier Elemento,Heng Pan,Jude M. Phillip,Richard J. O'Reilly,Benjamin E. Gewurz,Benjamin E. Gewurz,Ethel Cesarman,Lisa Giulino-Roth +19 more
TL;DR: Decitabine is identified as a potent inducer of immunogenic EBV antigens including LMP1, EBNA2 and EBNA3C and highlighted in a novel therapeutic approach to sensitize EBV+ lymphomas to immunotherapy.
Journal ArticleDOI
Epigenetic and Posttranscriptional Regulation of CD16 Expression during Human NK Cell Development
Aaron R. Victor,Christoph Weigel,Steven D. Scoville,Wing Keung Chan,Kelsey Chatman,Mary M. Nemer,Charlene Mao,Karen A. Young,Jianying Zhang,Jianhua Yu,Aharon G. Freud,Christopher C. Oakes,Michael A. Caligiuri +12 more
TL;DR: A system of FCGR3A regulation in human NK cells is proposed in which CpG dinucleotide sequences and concurrent DNA methylation confer developmental and cell type–specific transcriptional regulation, whereas miR-218 provides an additional layer of posttranscriptional regulation during the maturation process.