Christopher B. Newgard

TL;DR: In this chapter, recent studies employing molecular approaches for dissecting the relative contributions of glucose transport and glucose phosphorylation in the control of glucose-stimulated insulin release will be reviewed.

TL;DR: Differential screening strategies designed at identifying other genes that might be involved in the expansion of β-cell mass are developed, to prevent chronic calcifying pancreatitis.

TL;DR: It is demonstrated that neither the 2F5 bnAb nor HIV MPER-KYNU cross-reactive Abs elicited by immunization with an MPER peptide-liposome vaccine in 2F4 VHDJH and VLJL knock-in mice and rhesus macaques modified KYNU activity or disrupted tissue tryptophan metabolism.

TL;DR: In this article , the relative contributions of these two enzymes to hepatic AcCoA pools and DNL rates in response to high-fat feeding are unknown, however, the hepatocyte ACLY depletion in obese mice paradoxically increased total D2O incorporation into palmitate, whereas in contrast, ACSS2 depletion had no effect.

TL;DR: In this article, the application of genetic engineering to provide artificial β cells, i.e. cells which can secrete insulin in response to glucose, is discussed, which is achieved preferably through the introduction of one or more genes selected from the insulin gene, glucokinase gene and glucose transporter gene, so as to provide an engineered cell having all three of these genes in a biologically functional and responsive configuration.