C
Christopher B. Newgard
Researcher at Duke University
Publications - 483
Citations - 55811
Christopher B. Newgard is an academic researcher from Duke University. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 111, co-authored 460 publications receiving 49018 citations. Previous affiliations of Christopher B. Newgard include Durham University & University of Texas at Austin.
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Journal ArticleDOI
Biochemical Mechanism of Lipid-induced Impairment of Glucose-stimulated Insulin Secretion and Reversal with a Malate Analogue
Anne Boucher,Danhong Lu,Shawn C. Burgess,Sabine Telemaque-Potts,Mette V. Jensen,Hindrik Mulder,May-Yun Wang,Roger H Unger,A. Dean Sherry,Christopher B. Newgard +9 more
TL;DR: It is concluded that chronic exposure of islet β-cells to fatty acids grossly alters a mitochondrial pathway of pyruvate metabolism that is important for normal GSIS.
Journal ArticleDOI
Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance.
Cynthia A. Nagle,Jie An,Masakazu Shiota,Tracy P. Torres,Gary W. Cline,Zhen Xiang Liu,Shuli Wang,ReEtta L. Catlin,Gerald I. Shulman,Gerald I. Shulman,Christopher B. Newgard,Rosalind A. Coleman +11 more
TL;DR: It is indicated that increased flux through the pathway of hepatic de novo triacylglycerol synthesis can cause hepatic and systemic insulin resistance in the absence of obesity or a lipogenic diet.
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Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions
Nicholas W. Griffin,Philip P. Ahern,Jiye Cheng,Andrew C. Heath,Olga Ilkayeva,Christopher B. Newgard,Luigi Fontana,Jeffrey I. Gordon +7 more
TL;DR: This work identified DP-associated gut bacterial taxa in individuals either practicing chronic calorie restriction with adequate nutrition (CRON) or without dietary restrictions (AMER), and transplanted into gnotobiotic mice, AMER and CRON microbiota responded predictably to CRON and AMER diets but with variable response strengths.
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Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism
Andrew Shin,Martin Fasshauer,Nika Filatova,Linus A. Grundell,Elizabeth Zielinski,Jian-Ying Zhou,Thomas Scherer,Claudia Lindtner,Phillip J. White,Amanda L. Lapworth,Olga Ilkayeva,Uwe Knippschild,Anna Maria Wolf,Ludger Scheja,Kevin L. Grove,Richard D. Smith,Wei-Jun Qian,Christopher J. Lynch,Christopher B. Newgard,Christoph Buettner +19 more
TL;DR: It is shown in rats that insulin dose-dependently lowers plasma BCAA levels through induction of hepatic protein expression and activity of branched-chain α-keto acid dehydrogenase (BCKDH), the rate-limiting enzyme in the BCAA degradation pathway.
Journal ArticleDOI
Mitochondrial Metabolism Sets the Maximal Limit of Fuel-stimulated Insulin Secretion in a Model Pancreatic Beta Cell A SURVEY OF FOUR FUEL SECRETAGOGUES
TL;DR: It is proposed that fuel-stimulated secretion is in fact limited by the inherent thermodynamic constraints of proton gradient formation.