C
Christopher Buckley
Researcher at GE Healthcare
Publications - 103
Citations - 3020
Christopher Buckley is an academic researcher from GE Healthcare. The author has contributed to research in topics: Positron emission tomography & Microscope. The author has an hindex of 24, co-authored 93 publications receiving 2519 citations. Previous affiliations of Christopher Buckley include Newcastle University & King's College London.
Papers
More filters
Journal ArticleDOI
18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment : a phase 2 trial.
Rik Vandenberghe,Rik Vandenberghe,Koen Van Laere,Adrian Ivanoiu,Eric Salmon,Christine Bastin,Eric Triau,Steen G. Hasselbalch,Ian Law,Allan R. Andersen,Alex Korner,Lennart Minthon,Gaëtan Garraux,Natalie Nelissen,Guy Bormans,Christopher Buckley,Rikard Owenius,Lennart Thurfjell,Gill Farrar,David J. Brooks,David J. Brooks +20 more
TL;DR: Validation of the 18F‐labeled PIB derivative18F‐flutemetamol could significantly enhance access to in vivo β‐amyloid imaging technology.
Journal ArticleDOI
Phase 3 Trial of Flutemetamol Labeled With Radioactive Fluorine 18 Imaging and Neuritic Plaque Density
Craig Curtis,Jose Gamez,Upinder Singh,Carl H. Sadowsky,Teresa Villena,Marwan N. Sabbagh,Thomas G. Beach,Ranjan Duara,Adam S. Fleisher,Adam S. Fleisher,Kirk A. Frey,Zuzana Walker,Zuzana Walker,Arvinder Hunjan,Clive Holmes,Yavir M. Escovar,Carla X. Vera,Marc Agronin,Joel Ross,Andrea Bozoki,Mary Akinola,Jiong Shi,Rik Vandenberghe,Milos D. Ikonomovic,Paul Sherwin,Igor D. Grachev,Igor D. Grachev,G. Farrar,Adrian Smith,Christopher Buckley,Richard McLain,Stephen Salloway,Stephen Salloway +32 more
TL;DR: This study showed that flutemetamol injection labeled with radioactive fluorine 18 was safe and had high sensitivity and specificity in an end-of-life population and may increase diagnostic accuracy in cognitively impaired patients.
Journal ArticleDOI
Whole-Body Biodistribution and Radiation Dosimetry of 18F-GE067: A Radioligand for In Vivo Brain Amyloid Imaging
Michel Koole,Dewi M. Lewis,Christopher Buckley,Natalie Nelissen,Mathieu Vandenbulcke,David J. Brooks,Rik Vandenberghe,Koen Van Laere +7 more
TL;DR: The estimated effective dose of 18F-GE067 for PET amyloid imaging was acceptable (class II-b defined by the World Health Organization), and relatively low variability between subjects was observed.
Journal ArticleDOI
Automated Quantification of 18F-Flutemetamol PET Activity for Categorizing Scans as Negative or Positive for Brain Amyloid: Concordance with Visual Image Reads
Lennart Thurfjell,Lennart Thurfjell,Johan Lilja,Roger Lundqvist,Christopher Buckley,Adrian Smith,Rik Vandenberghe,Rik Vandenberghe,Paul Sherwin +8 more
TL;DR: Categorization of 18F-flutemetamol amyloid imaging data using an automated PET-only quantification method showed good agreement with histopathologic classification of neuritic plaque density and a strong concordance with visual read results.
Journal ArticleDOI
Association between in vivo fluorine 18-labeled flutemetamol amyloid positron emission tomography imaging and in vivo cerebral cortical histopathology.
David A. Wolk,Igor D. Grachev,Christopher Buckley,Hala Kazi,M. Sean Grady,John Q. Trojanowski,Roy H. Hamilton,Paul Sherwin,Richard McLain,Steven E. Arnold +9 more
TL;DR: These data are the first to demonstrate the concordance of ¹⁸F-flutemetamol PET imaging with histopathology, supporting its sensitivity to detect amyloid and potential use in the study and detection of Alzheimer disease.