C
Christopher M. Lambert
Researcher at University of Massachusetts Medical School
Publications - 18
Citations - 934
Christopher M. Lambert is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Dendritic spine & Postsynaptic potential. The author has an hindex of 9, co-authored 15 publications receiving 831 citations. Previous affiliations of Christopher M. Lambert include University of Massachusetts Amherst.
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Journal ArticleDOI
A Clock Shock: Mouse CLOCK Is Not Required for Circadian Oscillator Function
Jason P. DeBruyne,Elizabeth Noton,Christopher M. Lambert,Elizabeth S. Maywood,David R. Weaver,Steven M. Reppert +5 more
TL;DR: The Cre-LoxP system is used to generate whole-animal knockouts of CLOCK and the resultant circadian phenotypes challenge a central feature of the current mammalian circadian clock model regarding the necessity of CLock:BMAL1 heterodimers for clock function.
Journal ArticleDOI
Casein kinase 1 delta regulates the pace of the mammalian circadian clock.
Jean-Pierre Etchegaray,Kazuhiko K. Machida,Elizabeth Noton,Cara M. Constance,Robert Dallmann,Marianne N. Di Napoli,Jason P. DeBruyne,Christopher M. Lambert,Elizabeth A. Yu,Steven M. Reppert,David R. Weaver +10 more
TL;DR: CK1δ plays an unexpectedly important role in maintaining the 24-h circadian cycle length, and disruption of the gene encoding CK1ε did not alter these circadian endpoints.
Journal ArticleDOI
Neurexin directs partner-specific synaptic connectivity in C. elegans
Alison Philbrook,Shankar Ramachandran,Christopher M. Lambert,Devyn Oliver,Jeremy Florman,Mark J. Alkema,Michele L. Lemons,Michele L. Lemons,Michael M. Francis +8 more
TL;DR: The data indicate that NRX-1 located at presynaptic sites specifically directs postsynaptic development in GABAergic neurons, providing evidence that individual neurons can direct differential patterns of connectivity with their post-synaptic partners through partner-specific utilization of synaptic organizers.
Journal ArticleDOI
Distinct patterns of Period gene expression in the suprachiasmatic nucleus underlie circadian clock photoentrainment by advances or delays
William J. Schwartz,Mahboubeh Tavakoli-Nezhad,Christopher M. Lambert,David R. Weaver,Horacio O. de la Iglesia +4 more
TL;DR: The results suggest that the underlying molecular mechanisms of circadian entrainment differ with morning (advancing) or evening (delaying) light exposure, and such differences may reflect howEntrainment takes place in nocturnal animals under natural conditions.
Journal ArticleDOI
Analysis of the prokineticin 2 system in a diurnal rodent, the unstriped Nile grass rat (Arvicanthis niloticus).
TL;DR: There is no clear evidence indicating that a difference in the PK2 ligand/receptor system accounts for diurnality in this rodent species, and data contribute to a growing body of evidence suggesting that the key to diurnity lies downstream of the SCN in A. niloticus.